Journal List > Korean J Gastroenterol > v.67(5) > 1007512

Song, Sohn, Jeong, Min, Choi, Kim, and Pyo: Repeated Panniculitis Induced by Pegylated Interferon Alpha 2a in a Patient with Chronic Hepatitis C

Abstract

Pegylated interferon alpha (PEG-IFN-α) is widely used to treat chronic hepatitis C in combination with ribavirin. Many adverse effects of PEG-IFN-α, such as hematologic, psychologic, dermatologic, immunologic, and other abnormalities, have been reported, and some serious adverse events lead to PEG-IFN-α treatment discontinuation. For very rare adverse events such as panniculitis, there are no established guidelines on whether to continue PEG-IFN-α treatment. Published reports on panniculitis induced by PEG-IFN-α 2a are sparse. Herein we report a case of repeated occurrences of panniculitis in a patient with chronic hepatitis C, leading to treatment cessation.

References

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Fig. 1.
The skin lesion was reddish and edematous, and the size of subcutaneous nodule was 6×6 cm.
kjg-67-272f1.tif
Fig. 2.
Ultrasonographic findings. Soft tissue ultrasound shows cellulitis, panniculitis and myositis of the left abdominal wall compatible with chemical-induced inflammation.
kjg-67-272f2.tif
Fig. 3.
Microscopic findings of the punch biopsy specimen (H&E). (A) Histology of bisected tissue section of abdominal skin lesion (×12.5). (B) Superficial perivascular and interstitial lymphocytic infiltrates (×100). (C) Deep perivascular and interstitial lymphocytic infiltrates (×200) (arrows).(D) In deep dermis, a few degenerated adipocytes with lymphocytic infiltration (×200) (arrow).
kjg-67-272f3.tif
Fig. 4.
Microscopic findings of typical panniculitis. Lobular panniculitis with mixed infiltration of lymphocyte and plasma cell (H&E, ×40). Courtesy of Yoo et al. (Korean J Dermatol 2012;50:640–643).
kjg-67-272f4.tif
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