Journal List > Korean J Gastroenterol > v.65(6) > 1007388

Jeon, Park, Kim, Yu, Park, and Kim: A Case of Lead Poisoning with Drug-induced Liver Injury

Abstract

A 61-year-old male patient was admitted because of unexplained abdominal pain and anemia. His past medical history was unremarkable except for having taken herbal medicine to treat facial palsy two months ago. The result of health examination performed about a month ago showed increased serum aspartate and alanine aminotransferase level, and he was diagnosed with toxic hepatitis by herbal medicine. When the patient presented to the outpatient department three weeks ago, follow-up liver function test results showed improvement but he complained of abdominal pain. Despite extensive blood chemistry tests and computed tomography, the cause of pain could not be found. After much deliberation, serum lead level and herbal medicines analysis was performed based on the fact that he took herbal medicine two months ago, and he could finally be diagnosed with lead poisoning. Since the serum lead level was high enough to be indicated for lead chelating therapy, conservative management was given. When a patient with toxic hepatitis due to herbal medication presents with abdominal pain, the possibility of lead poisoning should always be taken into consideration.

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Fig. 1.
Change in serum hemoglobin level. Serum hemoglobin (Hb) level gradually declined up until transfusion was given (white arrow). The hemoglobin level at first visit after discharge (black arrow) remains similar to that after transfusion and shows slow recovery during follow-up period after discharge.
kjg-65-375f1.tif
Fig. 2.
Changes in AST, ALT, and total billirubin. AST, ALT, and total bilirubin all improved with time.
kjg-65-375f2.tif
Table 1.
Analysis on Lead Quantity in Patient's Herbal Medicine
Herbal medicine type Lead content
Herbal powder I 25.229 mg/g
Herbal powder II 10.269 mg/g
Herbal pill I 0.2327 μ g/g
Herbal pill II 0.3842 μ g/g
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