Abstract
Protein-calorie malnutrition and deficiencies of specific nutrients could commonly occur in various types of gastrointestinal diseases. These nutritional problems could delay recovery from diseases, resulting in increased morbidity and mortality, and impairment of quality of life. Parenteral nutrition (PN) is one of the methods of nutritional support through which macronutrients (glucose, amino acids, and triglycerides), micronutrients (vitamins and trace elements), water, and electrolytes are administered via peripheral or central venous route. PN could play an important role for patients for whom enteral/oral feeding is contraindicated or cannot meet the patients' requirement for adequate nutrition due to anatomical and/or functional problems. Since insufficient and excessive PN supplement could both be harmful for patients, it is very important to adhere to correct indication, optimal timing, and dosage/composition of PN. In this article, the current role of PN for various gastrointestinal diseases will be reviewed and discussed.
References
2. Riegel C, Kopp CE, Schwegman CW, Barnes MT, Grigger RP. An evaluation of mixtures of ossein gelatin, hydrolyzed protein, a and glucose in the parenteral nutrition of postoperative patients. Surgery. 1949; 25:672–675.
3. Mann GV, Geyer RP. Parenteral nutrition; fat emulsions for intravenous nutrition in man. J Lab Clin Med. 1949; 34:699–712.
4. Alastair F, Emma G, Emma P. Nutrition in inflammatory bowel disease. JPEN J Parenter Enteral Nutr. 2011; 35:571–580.
5. Massironi S, Rossi RE, Cavalcoli FA, Della Valle S, Fraquelli M, Conte D. Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches. Clin Nutr. 2013; 32:904–910.
6. Van Gossum A, Cabre E, Hébuterne X, et al. ESPEN guidelines on parenteral nutrition: gastroenterology. Clin Nutr. 2009; 28:415–427.
7. Geerling BJ, Badart-Smook A, Stockbrügger RW, Brummer RJ. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr. 2000; 54:514–521.
8. O'Sullivan M, O'Morain C. Nutrition in inflammatory bowel disease. Best Pract Res Clin Gastroenterol. 2006; 20:561–573.
9. Yoon SY, Jung SA. Nutritional support in patients with inflammatory bowel diseases. Intest Res. 2013; 11:243–249.
10. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child. 2003; 88:995–1000.
11. Sentongo TA, Semeao EJ, Piccoli DA, Stallings VA, Zemel BS. Growth, body composition, and nutritional status in children and adolescents with Crohn's disease. J Pediatr Gastroenterol Nutr. 2000; 31:33–40.
12. Triantafillidis JK, Papalois AE. The role of total parenteral nutrition in inflammatory bowel disease: current aspects. Scand J Gastroenterol. 2014; 49:3–14.
13. Afonso JJ, Rombeau JL. Nutritional care for patients with Crohn's disease. Hepatogastroenterology. 1990; 37:32–41.
14. Druyan ME, Compher C, Boullata JI, et al. Clinical guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients: applying the GRADE system to development of A.S.P.E.N. clinical guidelines. JPEN J Parenter Enteral Nutr. 2012; 36:77–80.
15. Jones VA. Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn's disease. Longterm maintenance of remission by personalized food exclusion diets. Dig Dis Sci. 1987; 32(12 Suppl):100S–107S.
16. Dickinson RJ, Ashton MG, Axon AT, Smith RC, Yeung CK, Hill GL. Controlled trial of intravenous hyperalimentation and total bowel rest as an adjunct to the routine therapy of acute colitis. Gastroenterology. 1980; 79:1199–1204.
17. McIntyre PB, Powell-Tuck J, Wood SR, et al. Controlled trial of bowel rest in the treatment of severe acute colitis. Gut. 1986; 27:481–485.
18. Greenberg GR, Fleming CR, Jeejeebhoy KN, Rosenberg IH, Sales D, Tremaine WJ. Controlled trial of bowel rest and nutritional support in the management of Crohn's disease. Gut. 1988; 29:1309–1315.
19. Braga M, Ljungqvist O, Soeters P, Fearon K, Weimann A, Bozzetti F. ESPEN guidelines on parenteral nutrition: surgery. Clin Nutr. 2009; 28:378–386.
20. Gouma DJ, von Meyenfeldt MF, Rouflart M, Soeters PB. Preoperative total parenteral nutrition (TPN) in severe Crohn's disease. Surgery. 1988; 103:648–652.
21. ASPEN Board of Directors and the Clinical Guidelines Task Force. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN J Parenter Enteral Nutr. 2002; 26(1 Suppl):1SA–138SA.
22. Jacobson S. Early postoperative complications in patients with Crohn's disease given and not given preoperative total parenteral nutrition. Scand J Gastroenterol. 2012; 47:170–177.
24. Bollhalder L, Pfeil AM, Tomonaga Y, Schwenkglenks M. A systematic literature review and metaanalysis of randomized clinical trials of parenteral glutamine supplementation. Clin Nutr. 2013; 32:213–223.
25. Ockenga J, Borchert K, Stüber E, Lochs H, Manns MP, Bischoff SC. Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease. Eur J Clin Nutr. 2005; 59:1302–1309.
26. Markel TA, Lou DC, Pfefferkorn M, et al. Steroids and poor nutrition are associated with infectious wound complications in children undergoing first stage procedures for ulcerative colitis. Surgery. 2008; 144:540–545.
27. González-Huix F, Fernández-Bañares F, Esteve-Comas M, et al. Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis. Am J Gastroenterol. 1993; 88:227–232.
28. Nguyen GC, Laveist TA, Brant SR. The utilization of parenteral nutrition during the in-patient management of inflammatory bowel disease in the United States: a national survey. Aliment Pharmacol Ther. 2007; 26:1499–1507.
29. Salinas H, Dursun A, Konstantinidis I, et al. Does preoperative total parenteral nutrition in patients with ulcerative colitis produce better outcomes? Int J Colorectal Dis. 2012; 27:1479–1483.
30. Buchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology. 2003; 124:1111–1134.
31. DiBaise JK, Young RJ, Vanderhoof JA. Intestinal rehabilitation and the short bowel syndrome: part 1. Am J Gastroenterol. 2004; 99:1386–1395.
32. Wales PW, de Silva N, Kim J, Lecce L, To T, Moore A. Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates. J Pediatr Surg. 2004; 39:690–695.
33. Lal S, Teubner A, Shaffer JL. Review article: intestinal failure. Aliment Pharmacol Ther. 2006; 24:19–31.
34. Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med. 2000; 132:525–532.
35. Sundaram A, Koutkia P, Apovian CM. Nutritional management of short bowel syndrome in adults. J Clin Gastroenterol. 2002; 34:207–220.
36. Ziegler MM. Short bowel syndrome: remedial features that influence outcome and the duration of parenteral nutrition. J Pediatr. 1997; 131:335–336.
37. Purdum PP 3rd, Kirby DF. Short-bowel syndrome: a review of the role of nutrition support. JPEN J Parenter Enteral Nutr. 1991; 15:93–101.
38. Klein S. Influence of nutrition support on clinical outcome in short bowel syndrome and inflammatory bowel disease. Nutrition. 1995; 11(2 Suppl):233–237.
40. Berger DL, Malt RA. Management of the short gut syndrome. Adv Surg. 1996; 29:43–57.
41. Matarese LE, Jeppesen PB, O'Keefe SJ. Short bowel syndrome in adults: the need for an interdisciplinary approach and coordi-nated care. JPEN J Parenter Enteral Nutr. 2014; 38(1 Suppl):60S–64S.
42. Baldassano S, Amato A. GLP-2: what do we know? What are we going to discover? Regul Pept. 2014; 194–195:6–10.
43. McKeage K. Teduglutide: a guide to its use in short bowel syndrome. Clin Drug Investig. 2015; 35:335–340.
44. Jeppesen PB, Pertkiewicz M, Messing B, et al. Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology. 2012; 143:1473–1481.e3.
45. Jeppesen PB, Fujioka K, Youssef NN, O'Keefe SJ. PP101-MON: long-term safety and efficacy of teduglutide treatment for intestinal failure associated with short bowel syndrome (SBS-IF): final results of a 2-year, multicenter, open-label, clinical trial. Clin Nutr. 2014; 33(Suppl 1):S167.
46. Plauth M, Cabré E, Campillo B, et al. ESPEN guidelines on parenteral nutrition: hepatology. Clin Nutr. 2009; 28:436–444.
47. Mendenhall CL, Tosch T, Weesner RE, et al. VA cooperative study on alcoholic hepatitis. II: prognostic significance of protein-calo-rie malnutrition. Am J Clin Nutr. 1986; 43:213–218.
48. Mendenhall CL, Moritz TE, Roselle GA, et al. A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs cooperative study. Hepatology. 1993; 17:564–576.
49. Mendenhall CL, Moritz TE, Roselle GA, et al. The VA Cooperative Study Group #275. Protein energy malnutrition in severe alcoholic hepatitis: diagnosis and response to treatment. JPEN J Parenter Enteral Nutr. 1995; 19:258–265.
50. Nutritional status in cirrhosis. Italian multicentre cooperative project on nutrition in liver cirrhosis. J Hepatol. 1994; 21:317–325.
51. Wicks C, Somasundaram S, Bjarnason I, et al. Comparison of enteral feeding and total parenteral nutrition after liver transplantation. Lancet. 1994; 344:837–840.
52. Naylor CD, O'Rourke K, Detsky AS, Baker JP. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. A metaanalysis. Gastroenterology. 1989; 97:1033–1042.
53. Gluud LL, Dam G, Les I, et al. Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2015; 2:CD001939.
54. Gianotti L, Meier R, Lobo DN, et al. ESPEN guidelines on parenteral nutrition: pancreas. Clin Nutr. 2009; 28:428–435.
55. McClave SA, Chang WK, Dhaliwal R, Heyland DK. Nutrition support in acute pancreatitis: a systematic review of the literature. JPEN J Parenter Enteral Nutr. 2006; 30:143–156.
56. Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev. 2010; (1):CD002837.
57. Dejong CH, Greve JW, Soeters PB. Nutrition in patients with acute pancreatitis. Curr Opin Crit Care. 2001; 7:251–256.
58. Wang X, Li W, Li N, Li J. Omega-3 fatty acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis: a randomized and controlled study. JPEN J Parenter Enteral Nutr. 2008; 32:236–241.
59. de Beaux AC, O'Riordain MG, Ross JA, Jodozi L, Carter DC, Fearon KC. Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition. 1998; 14:261–265.
60. Ockenga J, Borchert K, Rifai K, Manns MP, Bischoff SC. Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin Nutr. 2002; 21:409–416.
61. He X, Ma Q, Lu J, Chu Y, Du X. Effect of total parenteral nutrition (TPN) with and without glutamine dipeptide supplementation on outcome in severe acute pancreatitis (SAP). Clin Nutr Suppl. 2004; 1:43–47.
62. Sahin H, Mercanligil SM, Inanç N, Ok E. Effects of gluta-mine-enriched total parenteral nutrition on acute pancreatitis. Eur J Clin Nutr. 2007; 61:1429–1434.
63. Fuentes-Orozco C, Cervantes-Guevara G, Muciño-Hernández I, et al. L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. JPEN J Parenter Enteral Nutr. 2008; 32:403.
64. Xue P, Deng LH, Xia Q, et al. Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage. World J Gastroenterol. 2008; 14:474–478.