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Abstract
Background/Aims
Infliximab was approved for the treatment of ulcerative colitis (UC) in 2006 and has recently been used as rescue therapy in steroid-refractory UC. The aim of this study was to investigate the differences of medication use and prognosis in UC patients according to the periods of diagnosis.
Methods
From 1987 to 2012, a total of 1,422 patients with UC were retrospectively reviewed in 12 hospitals. The study population was divided into two groups according to the periods of diagnosis as follows; group A: 1987–2005, group B: 2006–2012. Analyzed variables were compared by using chi-square test and logistic regression analysis.
Results
Mean age of the subjects was 42.2 years, and the mean follow-up period was 4.7 years. In univariate analysis, the use of infliximab in group B was significantly higher than group A (4.5% vs. 7.6%, p=0.016), and UC-related hospitalization (45.8% vs. 40.1%, p=0.031) and UC-related surgery (6.4% vs. 3.5%, p=0.010) in group B was significantly lower than that of group A. The use of oral steroid in surgery group was significantly higher than non-surgery group in multivariate analysis (OR 1.85, 95% CI 1.03–3.30, p=0.039).
References
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Table 1.
Demographic and Clinical Characteristics of Subjects (n=1,422)
Table 2.
Comparison of Parameters between the Groups
Table 3.
Comparison of Parameters between Subjects with or without Surgery
Table 4.
Logistic Regression Analysis of Dependent Variables for Ulcerative Colitis-related Surgery
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