Journal List > Korean J Gastroenterol > v.64(1) > 1007290

Choi, Kim, Oh, Jang, Hwang, Kim, Kwon, and Jung: Factors Influencing the Miss Rate of Polyps in a Tandem Colonoscopy Study

Abstract

Background/Aims

The miss rate of colon polyps and its related factors have not been clearly identified yet. This study aims to review the miss rate of polyps both on the patient-level and on the polyp-level and to analyze the factors affecting the miss rate such as those related to the endoscopist, procedure, patient, and polyp.

Methods

From August 2011 to August 2013, patients who underwent elective second colonoscopy for resection of polyps, the sizes of which were not small enough to be resected by biopsy forceps alone at first colonoscopy, were enrolled retrospectively. Results: The miss rate on the patient-level was 59.2% (234/395) and on the polyp-level was 27.9% (578/2,068). There was no significant difference in the miss rate depending on the experience of the endoscopists or characteristics of the patients. In terms of the procedure, the miss rate was higher when the colonoscopy was performed in the afternoon (OR 1.632, p=0.046). It was found that the miss rate of polyps increased when the polyps were small (OR 4.595, p<0.001 in <5 mm/OR 3.447, p<0.001 in 5–10 mm), flat or sessile (OR 2.406, p<0.001 in flat/OR 1.768, p=0.002 in sessile), and located in the left colon (OR 1.391, p=0.007).

Conclusions

The experience of endoscopists did not have influence on the accuracy of polyp detection. However, the fatigue of endoscopists in the afternoon is considered to render polyp detection less accurate. Also, the large curves and folds of the sigmoid colon are regarded as a reason for the higher miss rate of polyps in the left colon.

References

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Fig. 1.
Comparison of miss rate of polyps between different groups of colonoscopists.
kjg-64-24f1.tif
Table 1.
Univariate and Multivariate Anaylsis of 395 Patients on the Association of Procedure-related Variables and Miss Rate of Polyps
Variable Univariate Multivariate
Non-missed Missed p-value OR 95% CI for OR p-value
Intubation time            
Index (min) 20.64±75.99 13.99±12.63 0.361      
Follow up (min) 7.35±8.74 5.58±3.39 0.070      
Withdrawal time            
Index (min) 18.30±13.22 21.17±13.65 0.060      
Follow up (min) 28.37±16.69 33.93±18.59 0.003 1.009 0.994–1.023 0.232
Preparation solution of first colonoscopy            
Coolprep 22 (18.03) 46 (25.56) 0.125      
Colyte 100 (81.97) 134 (74.44)        
Bowel preparation scale of first colonoscopy            
Exellent/good 85 (58.62) 108 (53.20) 0.316      
Fair/inadequate 60 (41.38) 95 (46.80)        
Start time of first colonoscopy            
Before 1 p.m. 82 (63.57) 97 (51.87) 0.039 1
After 1 p.m. 47 (36.43) 90 (48.13)   1.632 1.008–2.642 0.046

Values are presented as mean±SD or n (%).

Table 2.
Univariate and Multivariate Anaylsis in 395 Patients for the Association of Patient-related Variables and Miss Rate of Polyps
Variable Univariate Multivariate
Non-missed Missed p-value OR 95% CI for OR p-value
Gender     0.004      
Male 100 (62.11) 177 (75.64)   1.296 0.772, 2.175 0.327
Female 61 (37.89) 57 (24.36)   1
Age (yr)     0.052      
<65 113 (70.20) 142 (60.70)        
≥65 48 (29.81) 92 (39.32)        
BMI (kg/m2)     0.154      
<23 60 (37.50) 100 (43.67)        
≥23, <25 42 (26.25) 67 (29.26)        
≥25 58 (36.25) 62 (27.07)        
Polyps in first colonoscopy 3.38 (3.25) 3.71 (2.55) 0.255      

Values are presented as n (%).

Table 3.
Univariate and Multivariate Anaylsis of 2,068 Polyps on the Association of Polyp-related Variables and Miss Rate of Polyps
Variable Univariate Multivariate
Non-missed Missed Miss rate (%) p-value OR 95% CI for OR p-value
Size (mm)       <0.001      
<5 535 (36.44) 321 (55.54) 37.50   4.595 3.234, 6.529 <0.001
≥5, <10 490 (33.38) 211 (36.51) 30.10   3.447 2.413, 4.924 <0.001
≥10 443 (30.18) 46 (7.96) 9.40   1
Shape       <0.001      
Flat 299 (20.47) 145 (25.44) 32.66   2.406 1.608, 3.601 <0.001
Sessile 924 (63.24) 383 (67.19) 29.30   1.768 1.224, 2.556 0.002
Pedunculated 238 (16.29) 42 (7.37) 15.00   1
Location       <0.001      
Left (DC, SC, rectum) 1,003 (68.79) 443 (76.64) 30.64   1.391 1.094, 1.768 0.007
Right (cecum, AC, HF, TC, SF) 455 (31.21) 135 (23.36) 22.88   1
Tissue       <0.001      
Hyperplastic polyp 167 (11.98) 75 (13.11) 30.99   1
Tubular adenoma 1,015 (72.81) 406 (70.98) 28.57   0.977 0.714, 1.336 0.883
Villous adenoma/villotubular adenoma 89 (6.38) 5 (0.87) 5.32   0.331 0.125, 0.878 0.026
Serrated adenoma 2 (0.14) 0 (0.00) 0.00   0.000 0.000, 0.000 0.999
CIS or cancer 27 (1.94) 3 (0.52) 10.00   0.557 0.156, 1.988 0.367
Othersinflammation, lymphoid tissue, granulation tissue) 94 (6.74) 83 (14.51) 46.89   1.927 1.266, 2.933 0.002

Values are presented as n (%).

DC, descending colon; SC, sigmoid colon; AC, ascending colon; HF, hepatic flexure; TC, transverse colon; SF, splenic flexure; CIS, carcinoma in situ.

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