Journal List > Korean J Gastroenterol > v.64(3) > 1007273

Koh and Lee: Adenocarcinoma of Lung Cancer with Solitary Metastasis to the Stomach

Abstract

Although hematogenous metastasis of cancer to the gastrointestinal track is rare, it sometime has been reported in patients with malignant melanoma and breast cancer. However, it is extremely rare for lung cancer to metastasize to the stomach, not to mention solitary gastric metastasis. Herein, the authors report a case of a 69-year-old man who was initially diagnosed with lung cancer with synchronous primary gastric cancer which proved to be lung cancer with solitary gastric metastasis after the operation.

References

1. Oh JC, Lee GS, Kim JS, et al. A case of gastric metastasis from small cell lung carcinoma. Korean J Gastroenterol. 2004; 44:168–171.
2. Park YS, Lee JW, Lim HJ, Lee GK, Hwangbo B, Lee HS. Gastric metastasis of primary lung adenocarcinoma mistaken for primary gastric cancer. Tuberc Respir Dis. 2009; 66:52–57.
crossref
3. Sileri P, D'Ugo S, Del Vecchio Blanco G, et al. Solitary metachro-nous gastric metastasis from pulmonary adenocarcinoma: report of a case. Int J Surg Case Rep. 2012; 3:385–388.
crossref
4. Annual report of cancer statistics in Korea in 2011. [Internet]. Annual report of cancer statistics in Korea in 2011. 2014 Apr 15. [cited 2014 Aug 20]. Available from:. http://ncc.re.kr/manage/manage03_033_view.jsp?bbsnum=295&hSelSearch=&hTxtKeyword=&current_page=1&cd=null.
5. Kim HG, Kim YS, Choi SD, et al. A case of squamous cell lung cancer with metastasis of the stomach. Korean J Gastrointest Endosc. 1998; 18:900–907.
6. Garwood RA, Sawyer MD, Ledesma EJ, Foley E, Claridge JA. A case and review of bowel perforation secondary to metastatic lung cancer. Am Surg. 2005; 71:110–116.
crossref
7. Hwang SY, Ahn DW, Yun WJ, et al. A case of gastric, duodenal and colonic metastases from adenocarcinoma of the lung. Korean J Gastrointest Endosc. 2010; 40:102–106.
8. Kanthan R, Sharanowski K, Senger JL, Fesser J, Chibbar R, Kanthan SC. Uncommon mucosal metastases to the stomach. World J Surg Oncol. 2009; 7:62.
crossref
9. Kim HS, Jang WI, Hong HS, et al. Metastatic involvement of the stomach secondary to lung carcinoma. J Korean Med Sci. 1993; 8:24–29.
crossref
10. Lee MH, Kim SR, Soh JS, Chung MJ, Lee YC. A solitary gastric metastasis from pulmonary adenocarcinoma: a case report. Thorax. 2010; 65:661–662.
crossref
11. Kaufmann O, Dietel M. Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology. 2000; 36:8–16.
crossref

Fig. 1.
Esophagogastroduodenoscopy shows convergence of the rugal folds with about 2.5 cm-sized central depression at anterior wall of greater curvature on mid-body.
kjg-64-154f1.tif
Fig. 2.
Chest computed tomography shows a 2.2 cm-sized spiculated nodule in right lower lung (A) and multiple calcified mediastinal and right hilar lymph nodes (B).
kjg-64-154f2.tif
Fig. 3.
Histologic findings of lung mass biopsy specimen. (A) Moderately differentiated adenocarcinoma of acinar type is observed (H&E, ×100).(B) The tumor cells show a strong positive staining for thyroid transcription factor-1 (×100).
kjg-64-154f3.tif
Fig. 4.
Histologic findings of the stomach operation specimen. (A) An undifferentiated diffuse proliferation, suggesting poorly differentiated adenocarcinoma, infiltrating to the submucosa layer with marked lymphovascular invasion is observed (H&E, ×100). (B) The tumor cells show a strong positive staining for thyroid transcription factor-1 (×100).
kjg-64-154f4.tif
TOOLS
Similar articles