Current Issues on the Treatment of Chronic Constipation

Kyoung Sup Hong; Kee Wook Jung; Tae Hee Lee; Bong Eun Lee; Sun-Young Park; Jeong Eun Shin; Seong-Eun Kim; Kyung Sik Park; Suck Chei Choi

doi:10.4166/kjg.2014.64.3.148

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Hong, Jung, Lee, Lee, Park, Shin, Kim, Park, and Choi: Current Issues on the Treatment of Chronic Constipation

Review Article

Korean J Gastroenterol 2014;64(3):148-153.

Published online: 4 October 2014

DOI: https://doi.org/10.4166/kjg.2014.64.3.148

Current Issues on the Treatment of Chronic Constipation

Kyoung Sup Hong, Kee Wook Jung¹, Tae Hee Lee², Bong Eun Lee³, Sun-Young Park⁴, Jeong Eun Shin⁵, Seong-Eun Kim⁶, Kyung Sik Park⁷, Suck Chei Choi⁸

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

¹Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

²Institute for Digestive Research, Soonchunhyang University College of Medicine, Seoul, Korea

³Departments of Internal Medicine, Pusan National University School of Medicine, Busan, Korea

⁴Chonnam National University Medical School, Gwangju, Korea

⁵Dankook University College of Medicine, Cheonan, Korea

⁶Ewha Womans University School of Medicine, Seoul, Korea

⁷Department of Internal Medicine and Institute for Medical Science, Keimyung University School of Medicine, Daegu, Korea

⁸Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea

Correspondence to: Suck Chei Choi, Department of Internal Medicine, Wonkwang University School of Medicine & Hospital, 895 Muwang-ro, Iksan 570-711, Korea. Tel: +82-63-859-2563, Fax: +82-63-855-2025, E-mail: medcsc@wmc.wonkwang.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic constipation is a very common clinical problem with its prevalence of up to 14% in the general population. It is not a life-threatening disease, but since patient's satisfaction to the treatment is known to be as low as 50%, chronic constipation still remains a clinically challenging problem. Fortunately, many new treatments have been introduced or are to be introduced in the near future. This article will review the basic concepts and the results of recent studies on the new treatments for chronic constipation.

Keywords: Constipation, Prucalopride, Lubiprostone, Linaclotide

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