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Choi, Kim, Kim, Lee, Jeong, Lee, Jung, Kim, Ahn, Kim, Joo, Chang, and Kwon: The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma
Original Article
Alimentary Tract
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 60(1): 36-41.

Published online: 20 July 2012

DOI: https://doi.org/10.4166/kjg.2012.60.1.36

The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma

Min Young Choi1, 3, Byeong Gwan Kim1, 3, Ji Won Kim1, 3, Kook Lae Lee1, 3, Ji Bong Jeong1, 3, Jae Kyung Lee1, 3, Yong Jin Jung1, 3, Won Kim1, 3, Dong Won Ahn1, 3, Young Hoon Kim1, 3, Sae Kyung Joo1, 3, Mee Soo Chang2, 3, Hyeoung Ju Kwon2, 3

1Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea.

2Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea.

3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Correspondence to: Byeong Gwan Kim, Department of Internal Medicine, Seoul National University Boramae Hospital, 5-gil 20, Boramae-ro, Dongjak-gu, Seoul 156-707, Korea. Tel: +82-2-870-2217, Fax: +82-2-870-3863, byeonggwankim@gmail.com

Received 25 January 2012       Revised 18 April 2012       Accepted 21 April 2012

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

Early detection of polyp is important for the prevention of colorectal cancer (CRC). There have been few studies to investigate the relationship between colorectal adenoma and family history of CRC (FHCRC) in Korea. The aim of this study was to identify the relationship between colorectal adenoma and FHCRC.

Methods

Between March 2009 and September 2010, 225 patients with adenomatous polyps were included. Their medical records with clinical history and size, numbers, histology of polyps were reviewed. Immunohistochemical staining using Bcl-2, Bax, p-AKT, NF-κB, and β-catenin antibodies were performed. We compared the histology of adenoma and expression of immunohistochemical staining according to the existence of FHCRC.

Results

The incidence of colorectal adenoma increased in case of FHCRC (p=0.029). In patients with FHCRC, the mean age of patients was 49 years old and younger than patients without FHCRC. In addition in patients with FHCRC, the incidence of advanced adenoma was significantly higher than in patients without FHCRC (p=0.001). The expression of Bax was significantly lower in patients with FHCRC than without FHCRC (p=0.046).

Conclusions

There was a tendency for polyp to develop in their younger ages and to be more advanced adenomas in patients with FHCRC. The low expression of Bax, tumor suppressor gene, might be associated with the development of polyps in patient with FHCRC. Therefore, patients with FHCRC may be better to start screening colonoscopy earlier than patient without FHCRC.

Keywords: Colorectal neoplasms, Colorectal adenoma, Family history of colorectal cancer, Bcl-2-associated X protein

Figures and Tables

Fig. 1
Immunohistochemical expression of Bax in patient with family history of colorectal cancer. The picture showed lower expression than those of control group (H&E, ×100).
Bax, Bcl-2-associated X protein.
kjg-60-36-g001
Fig. 2
Immunohistochemical expression of Bax in patient without family history of colorectal cancer. The picture showed higher expression than those of patient group (H&E, ×100).
Bax, Bcl-2-associated X protein.
kjg-60-36-g002
Table 1
The Relationship of Colonic Adenoma with Family History of Colorectal Cancer
kjg-60-36-i001

Values are presented as n (%).

Table 2
Characteristics of the Patients with Colonic Adenoma according to Family History of Colorectal Cancer
kjg-60-36-i002

Values are presented as mean±SD, n, or n (%).

Table 3
Characteristics of Colonic Adenoma according to Family History of Colorectal Cancer
kjg-60-36-i003

Values are presented as n (%).

aAnalyzed by generalized estimating equation, banalyzed by penalized maximum likelihood.

Table 4
Immunoexpressions of β-catenin, Bax, Bcl-2, NF-κB p65, p-AKT of Colonic Adenoma according to Family History of Colorectal Cancer
kjg-60-36-i004

Values are presented as n (%).

Bax, Bcl-2-associated X protein; NF-κB p65, nuclear factor kappa B p65; p-AKT, phosphorylated-AKT.

aAnalyzed by generalized estimating equation.

Notes

Financial support: None.

Notes

Conflict of interest: None.

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