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Jung: What Is the Effect of Metformin Combined to Chemotherapy in Stage IV Colorectal Cancer with Diabetes?
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The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 60(6): 343-344.

Published online: 17 December 2012

DOI: https://doi.org/10.4166/kjg.2012.60.6.343

What Is the Effect of Metformin Combined to Chemotherapy in Stage IV Colorectal Cancer with Diabetes?

Jin Tae Jung

Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

Correspondence to: Jin Tae Jung, Department of Internal Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea. Tel: +82-53-650-4217, Fax: +82-53-628-4005, jungjt@cu.ac.kr

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Notes

Financial support: None.

Conflict of interest: None.

References

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2. Schoen RE, Tangen CM, Kuller LH, et al. Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst. 1999. 91:1147–1154.
3. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol. 2005. 17:596–603.
4. Hosono K, Endo H, Takahashi H, et al. Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol Carcinog. 2010. 49:662–671.
5. Noto H, Goto A, Tsujimoto T, Noda M. Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One. 2012. 7:e33411.
6. Lee JH, Kim TI, Jeon SM, Hong SP, Cheon JH, Kim WH. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer. 2012. 131:752–759.
7. Tseng CH. Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan. Eur J Endocrinol. 2012. 167:409–416.
8. Lee DJ, Kim B, Lee JH, et al. The Effect of metformin on the response to chemotherapy and survival in stage IV colorectal cancer with diabetes. Korean J Gastroenterol. 2012. 60:355–361.
9. Higurashi T, Takahashi H, Endo H, et al. Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. BMC Cancer. 2012. 12:118.
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