Journal List > Korean J Gastroenterol > v.60(2) > 1006982

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Yang, Kim, Song, Chung, Lee, Hong, Lee, Kim, Yim, Park, Lim, and Kim: Dietary Risk Factors in Relation to Colorectal Adenoma
Original Article
Alimentary Tract
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 60(2): 102-108.

Published online: 22 August 2012

DOI: https://doi.org/10.4166/kjg.2012.60.2.102

Dietary Risk Factors in Relation to Colorectal Adenoma

Sun Young Yang, Young Sun Kim, Ji Hyun Song, Su Jin Chung, In Hee Lee1, Kyoung Ju Hong1, Eun Jung Lee1, Donghee Kim, Jeong Yoon Yim, Min Jung Park, Seon Hee Lim, Joo Sung Kim

Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.

1Department of Nutrition, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.

Correspondence to: Young Sun Kim, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, 39th fl., Gangnam Finance Center, 152 Teheran-ro, Gangnam-gu, Seoul 135-984, Korea. Tel: +82-2-2112-5638, Fax: +82-2-2112-5635, pandayoung@yahoo.co.kr

Received 8 February 2012       Revised 23 March 2012       Accepted 26 March 2012

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

The role of dietary risk factors in colorectal carcinogenesis remains unclear. We investigated the association between dietary intakes and colorectal adenomas who visited a health promotion center for a routine health check-up colonoscopy.

Methods

We conducted a retrospective case-control study using data from individuals who had colonoscopy at Seoul National University Hospital Healthcare System Gangnam Center from October 2003 to December 2007. The subjects were 242 patients (162 males and 80 females) with histopathologically confirmed colorectal adenoma, and 464 (272 males and 192 females) controls. Dietary data were obtained via 24 hour dietary recall, assisted by a registered dietitian. The student's t-test and the chi-square test were performed for the statistical comparison of means and proportions among groups. Multivariate analyses using logistic regression were performed to assess the relation between dietary intake and colorectal adenoma.

Results

The total average energy intake of the patients (male: 2,407.5±429.2 kcal, female: 1,901.3±316.9 kcal) was higher than the controls (male: 2,249.6±430.4 kcal, female: 1,752.4±275.0 kcal; p=0.001). High energy intake (male: OR=4.13, 95% CI=1.70-10.05, p=0.002; female: OR=4.00, 95% CI=1.51-10.61, p=0.005) and animal protein intake (male: OR=3.97, 95% CI=1.66-9.49, p=0.002; female: OR=5.76, 95% CI=1.99-16.169, p=0.001) were found to be associated with the risk of colorectal adenoma after adjusting for confounders such as age, BMI, waist circumference, metabolic syndrome and smoking.

Conclusions

In summary, high energy intake and animal protein were associated with colorectal adenoma.

Keywords: Colorectal neoplasms, Adenoma, Risk factors, Diet, Energy intake

Figures and Tables

Table 1
Baseline Characteristics of Patients with Colorectal Adenoma and the Controls
kjg-60-102-i001

Values are presented as mean±SD or n (%).

BP, blood pressure.

Table 2
Mean Nutrient Intakes of Patients with Colorectal Adenoma and the Controls
kjg-60-102-i002

Values are presented as mean±SD.

aKorean national health and nutrition examination survey, 2007.

Table 3
Mean Proportion of Energy from Carbohydrate, Protein and Fat of Subjects by Disease Status and Gender
kjg-60-102-i003

Values are presented as mean±SD.

aKorean national health and nutrition examination survey, 2007.

Table 4
Univariate Analysis Assessing the Independent Risk Factors for Colorectal Adenoma
kjg-60-102-i004
Table 5
Multivariate Analysis of Dietary Risk Factors for Colorectal Adenoma after Adjusted for Age, BMI, Waist Circumference, Smoking and Metabolic Syndrome
kjg-60-102-i005

Notes

Financial support: None.

Conflict of interest: None.

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