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Kim, Kim, Park, Jo, Shin, Lee, Park, Hwang, Kim, Jeong, Lee, Kim, Lee, Jung, and Song: Clinical Characteristics of Patients Diagnosed as Peptic Ulcer Disease in the Third Referral Center in 2007
Original Article
Alimentary Tract
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 59(5): 338-346.

Published online: 21 May 2012

DOI: https://doi.org/10.4166/kjg.2012.59.5.338

Clinical Characteristics of Patients Diagnosed as Peptic Ulcer Disease in the Third Referral Center in 2007

Jin Joo Kim1, Nayoung Kim1, 2, Hyun Kyung Park2, Hyun Jin Jo2, Cheol Min Shin2, Sang Hyup Lee1, 2, Young Soo Park1, 2, Jin-Hyeok Hwang1, 2, Jin-Wook Kim1, 2, Sook-Hyang Jeong1, 2, Dong Ho Lee1, 2, Jung Mogg Kim3, Ji Hyun Lee4, Hyun Chae Jung1, In Sung Song1

1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

3Department of Microbiology, Hanyang University School of Medicine, Seoul, Korea.

4Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Korea.

Correspondence to: Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro 173-gil, Bundang-gu, Seongnam 463-707, Korea. Tel: +82-31-787-7008, Fax: +82-31-787-4051, nayoungkim49@empal.com

Received 14 April 2011       Revised 14 June 2011       Accepted 16 June 2011

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

In spite of the improvement of medical treatment for the peptic ulcer disease (PUD), PUD is still one of the common upper gastrointestinal diseases. The purpose of this study was to evaluate the risk factors and general characteristics of Korean patients diagnosed as PUD at a single third referral center.

Methods

A total of 310 patients, diagnosed as PUD through endoscopy during one year of 2007 at Seoul National University Bundang Hospital were, retrospectively, evaluated regarding age, gender, Helicobacter pylori (H. pylori) positivity, clinical manifestations, comorbidities and medications. In addition, PUD was analyzed in the aspect of ulcer location, type of visit, gastrointestinal bleeding, and age.

Results

The mean age was 61.5 years old (48.1% over 65) and 208 (66.7%) patients were men. The rate of H. pylori infection was 47.8%, and any ulcerogenic medication history such as antiplatelet agents and NSAIDs was found to be 21.0% (65 patients). The rate of idiopathic peptic ulcer without evidence of H. pylori and NSAIDs was found to be 40.6% (126 patients). Among 310 PUD patients, bleeding symptoms such as melena, hematemesis and hematochezia occurred in 110 patients (35.5%).

Conclusions

PUD was more prevalent in the elderly patients and frequently associated with bleeding. Substantial proportion of PUD patients had neither H. pylori infection nor history of ulcerogenic medications, suggesting of increasing prevalence of idiopathic PUD.

Keywords: Peptic ulcer, Risk factors, Helicobacter pylori, Nonsteroidal anti-inflammatory drugs, Bleeding

Figures and Tables

Table 1
Characteristics of Patients Who Are Diagnosed as Peptic Ulcer Disease
kjg-59-338-i001

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 2
Comparisons of the Clinical Characteristics according to the Location of Peptic Ulcer Disease
kjg-59-338-i002

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 3
Comparisons of the Clinical Characteristics according to the Type of Visit
kjg-59-338-i003

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 4
Comparisons of the Clinical Characteristics according to the Clinical Symptoms Suggestive of UGI Bleeding
kjg-59-338-i004

Values are presented as mean±SD or n (%).

UGI, upper gastrointestinal; H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 5
Comparisons of the Clinical Characteristics according to Age
kjg-59-338-i005

Values are presented as n (%).

H. pylori, Helicobacter pylori.

aComorbidities include diabetes mellitus, cardiovascular disease, chronic lung disease, liver cirrhosis, chronic kidney disease; bUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 6
Relationship between H. pylori Positivity and Ulcerogenic Drugs
kjg-59-338-i006

Values are presented as n (%).

H. pylori, Helicobacter pylori.

aUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Table 7
Comparisons of the Clinical Characteristics according to the Etiology of Peptic Ulcer
kjg-59-338-i007

Values are presented as mean±SD or n (%).

H. pylori, Helicobacter pylori.

aUlcerogenic drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs, warfarin.

Notes

Financial support: This work was supported by a grant from Korean Health Insurance Review and Assessment Service Fund in 2008.

Conflict of interest: None.

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Nayoung Kim
https://orcid.org/http://orcid.org/0000-0002-9397-0406

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