Journal List > Korean J Gastroenterol > v.59(3) > 1006926

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Kwon, Kim, Lee, Jang, Park, Yang, Jung, Jeon, Cho, Tak, Kweon, and Kim: Could Nafamostat or Gabexate Prevent the Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?
Original Article
Pancreas and Biliary Tract
The Korean Journal of Gastroenterology

The Korean Journal of Gastroenterology 2012; 59(3): 232-238.

Published online: 21 March 2012

DOI: https://doi.org/10.4166/kjg.2012.59.3.232

Could Nafamostat or Gabexate Prevent the Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?

Yong Hwan Kwon, Ji Yeon Kim, Sang Jik Lee, Se Young Jang, Hyun Woo Park, Hae Min Yang, Min Kyu Jung, Seong Woo Jeon, Chang Min Cho, Won Young Tak, Young Oh Kweon, Sung Kook Kim

Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Correspondence to: Min Kyu Jung, Department of Gastroenterology, Kyungpook National University Hospital, 50 Samdeok-dong 2-ga, Jung-gu, Daegu 700-021, Korea. Tel: +82-53-420-5515, Fax: +82-53-426-8773, minky1973@Kornet.net

Received 12 May 2011       Revised 30 August 2011       Accepted 27 September 2011

Copyright © 2012 The Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

ERCP is the most common procedure for the diagnosis and treatment of bile duct and pancreatic disease, but Post-ERCP pancreatitis makes poor outcome in some cases. The protease inhibitors, nafamostat and gabexate, have been used to prevent pancreatitis related to ERCP, but there is some debate. We tried to evaluate the efficacy of gabexate and nafamostat for the prevention of post-ERCP pancreatitis.

Methods

Two hundred forty two patients (73 patients in the gabexate group, 88 patients in the nafamostat group and 81 patients in the placebo group) were included in the study after selective exclusion. The incidence of pancreatitis after ERCP was compared among groups.

Results

The incidence of pancreatitis were 6.8% in the gabexate group, 5.7% in the nafamostat group and 6.2% in the placebo group (p=0.954).

Conclusions

There was no meaningful difference among the gabexate, nafamostat and placebo group.

Keywords: Endoscopic retrograde cholangiopancreatography, Gabexate, Nafamostat

Figures and Tables

Fig. 1
The flow chart of patients in the gabexate, nafamostat and placebo group.
EBST, endoscopic biliary sphincterotomy.
kjg-59-232-g001
Table 1
Baseline Characteristics of Patients
kjg-59-232-i001

Values are presented as n (%) or mean±SD.

M, male; F, female; CBD, common bile duct.

Table 2
Baseline Characteristics of Patients according to Groups
kjg-59-232-i002

Values are presented as mean±SD or n (%).

EBST, endoscopic biliary sphincterotomy; EPST, endoscopic pancreatic sphincterotomy.

Table 3
Immediate Post-ERCP Complications
kjg-59-232-i003

Values are presented as n (%).

Table 4
Univariate Analysis for Risk of Post-ERCP Pancreatitis
kjg-59-232-i004

Values are presented as mean±SD or n (%).

EBST, endoscopic biliary sphincterotomy; EPST, endoscopic pancreatic sphincterotomy.

Notes

Financial support: None.

Conflict of interest: None.

References

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ORCID iDs

Won Young Tak
https://orcid.org/http://orcid.org/0000-0002-1914-5141

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