Journal List > Korean J Gastroenterol > v.59(3) > 1006926

Kwon, Kim, Lee, Jang, Park, Yang, Jung, Jeon, Cho, Tak, Kweon, and Kim: Could Nafamostat or Gabexate Prevent the Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?

Abstract

Background/Aims

ERCP is the most common procedure for the diagnosis and treatment of bile duct and pancreatic disease, but Post-ERCP pancreatitis makes poor outcome in some cases. The protease inhibitors, nafamostat and gabexate, have been used to prevent pancreatitis related to ERCP, but there is some debate. We tried to evaluate the efficacy of gabexate and nafamostat for the prevention of post-ERCP pancreatitis.

Methods

Two hundred forty two patients (73 patients in the gabexate group, 88 patients in the nafamostat group and 81 patients in the placebo group) were included in the study after selective exclusion. The incidence of pancreatitis after ERCP was compared among groups.

Results

The incidence of pancreatitis were 6.8% in the gabexate group, 5.7% in the nafamostat group and 6.2% in the placebo group (p=0.954).

Conclusions

There was no meaningful difference among the gabexate, nafamostat and placebo group.

Figures and Tables

Fig. 1
The flow chart of patients in the gabexate, nafamostat and placebo group.
EBST, endoscopic biliary sphincterotomy.
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Table 1
Baseline Characteristics of Patients
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Values are presented as n (%) or mean±SD.

M, male; F, female; CBD, common bile duct.

Table 2
Baseline Characteristics of Patients according to Groups
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Values are presented as mean±SD or n (%).

EBST, endoscopic biliary sphincterotomy; EPST, endoscopic pancreatic sphincterotomy.

Table 3
Immediate Post-ERCP Complications
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Values are presented as n (%).

Table 4
Univariate Analysis for Risk of Post-ERCP Pancreatitis
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Values are presented as mean±SD or n (%).

EBST, endoscopic biliary sphincterotomy; EPST, endoscopic pancreatic sphincterotomy.

Notes

Financial support: None.

Conflict of interest: None.

References

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Won Young Tak
https://orcid.org/http://orcid.org/0000-0002-1914-5141

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