Multiple Colonic Metastases from Hepatocellular Carcinoma

Gwi Hong Jeong; Byong Duk Ye; Seung Jae Myung

doi:10.4166/kjg.2011.58.5.288

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Jeong, Ye, and Myung: Multiple Colonic Metastases from Hepatocellular Carcinoma

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Korean J Gastroenterol 2011;58(5):288-292.

Published online: 4 October 2011

DOI: https://doi.org/10.4166/kjg.2011.58.5.288

Multiple Colonic Metastases from Hepatocellular Carcinoma

Gwi Hong Jeong, Byong Duk Ye, Seung Jae Myung

Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Correspondence to: Byong Duk Ye, Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-3181, Fax: +82-2-476-0824, E-mail: bdye@amc.seoul.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.

CT virtual colonoscopy. (A) A 24.5 mm-sized ulcerofungating mass was observed in the proximal descending colon. (B) A 6 mm-sized sessile polyp was also noted in the descending colon. (C) A 15 mm-sized low attenuated nodule suggesting metastatic tumor was noted in the left adrenal gland (arrow). Ulcerofungating mass in the proximal descending colon was also noted (arrowhead).

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Fig. 2.

Colonoscopic findings. (A) An about 25 mm-sized ovoid mass with central ulceration was noted in the proximal descending colon. The mucosa around ulceration showed similar feature compared with normal surrounding colonic mucosa. (B, C) Smaller tumors with similar morphologies with (A) were noted in the hepatic flexure and the descending colon.

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Fig. 3.

Histologic findings of metastatic sarcoid hepatocellular carcinoma. (A) The colonic crypts were normal and tumor cells infiltrating lamina propria were noted (H&E, ×100). (B) The tumor cells which had large, irregular and pale nuclei and spindle shaped cytoplasm were loosely infiltrating the lamina propria (H&E, ×400).(C) The tumor cells infiltrating the lamina propria were positive for vimentin (×100).

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Fig. 4.

The whole body PET showed multifocal hypermetabolic activities on the bones, left adrenal gland, pancreas, mesentery, lymph nodes, left lung, heart, right thigh muscle, and back muscle. This feature was compatible with disseminated metastatic tumors.

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