Crohn's Disease Presenting with Erythema Nodosum as an Early Sign: A Case Report

Seong Joo Kang; Won Moon; Moo In Park; Kyu Jong Kim; Jong Bin Kim; Mi Jung Park; Seun Ja Park; Hee Kyung Chang

doi:10.4166/kjg.2011.58.2.103

Journal List > Korean J Gastroenterol > v.58(2) > 1006843

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Kang, Moon, Park, Kim, Kim, Park, Park, and Chang: Crohn's Disease Presenting with Erythema Nodosum as an Early Sign: A Case Report

Case Report

Korean J Gastroenterol 2011;58(2):103-106.

Published online: 4 October 2011

DOI: https://doi.org/10.4166/kjg.2011.58.2.103

Crohn's Disease Presenting with Erythema Nodosum as an Early Sign: A Case Report

Seong Joo Kang, Won Moon, Moo In Park, Kyu Jong Kim, Jong Bin Kim, Mi Jung Park, Seun Ja Park, Hee Kyung Chang¹

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea

¹Department of Pathology, Kosin University College of Medicine, Busan, Korea

Correspondence to: Won Moon, Department of Internal Medicine, Kosin University Gospel Hospital, 34, Amnam-dong, Seo-gu, Busan 602-702, Korea. Tel: +82-51- 990-5205, Fax: +82-51-990-5055, E-mail: moonone70@hanmail.net

Received 18 February 201126 March 2011 Accepted 6 April 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Erythema nodosum is the most common form of septal panniculitis and the most frequent skin manifestation associated with inflammatory bowel disease, affecting up to 15% of Crohn's disease patients. Since the development of erythema nodosum is closely related with a variety of disorders and condition, it can serve as an important early sign of systemic disease. Here, we present the occurrence of erythema nodosum as an early sign of Cronh's disease in a 16-year-old woman.

Keywords: Erythema nodosum, Panniculitis, Skin, Inflammatory bowel disease, Crohn's disease

References

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Fig. 1.

Photograph of lower extremities on the first admission. It showed 1–5 cm sized multiple erythematous indurated subcutaneous nodules on the anterior aspect of the both lower extrimities.

Fig. 2.

Histopathologic finding of skin punch biopsy. It revealed the small and medium sized vessels infiltrated by lymphocytic aggregation in the deep dermis (H&E, ×200).

Fig. 3.

Colonoscopic finding of the transverse colon. It showed longitudinally arrayed, linear, active ulcers with several inflammatory pseudopolyps and normal looking background mucosa.

Fig. 4.

Upper gastrointestinal endoscopic finding. It showed multiple linear erythematous and erosive lesions on the antrum.

Fig. 5.

Histopathologic finding of gastric antral lesions. It showed granuloma-like lesion with lymphocyte aggregation (H&E, ×200).

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