Abstract
Mesenteric venous thrombosis is a clinically very rare disease, and may cause bowel infarction and gangrene. Difficulty in the dignosis the disease due to its non-specific symptoms and low prevalence can cause a clinically fatal situation. Mesenteric venous thrombosis may be caused by both congenital and acquired factors, and protein C deficiency, which is a very rare genetic disorder, is one of many causes of mesenteric thrombosis. The authors experienced a case of mesenteric venous thrombosis caused by protein C deficiency in a patient with duodenal ulcer bleeding, so here we report a case together with literature review.
References
1. Elliot JW. II. The operative relief of gangrene of intestine due to occlusion of the mesenteric vessels. Ann Surg. 1895; 21:9–23.
4. Abdu RA, Zakhour BJ, Dallis DJ. Mesenteric venous thrombosis–1911 to 1984. Surgery. 1987; 101:383–388.
5. Boley SJ, Kaleya RN, Brandt LJ. Mesenteric venous thrombosis. Surg Clin North Am. 1992; 72:183–201.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
7. Harward TR, Green D, Bergan JJ, Rizzo RJ, Yao JS. Mesenteric venous thrombosis. J Vasc Surg. 1989; 9:328–333.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
8. Kaleya RN, Sammartano RJ, Boley SJ. Aggressive approach to acute mesenteric ischemia. Surg Clin North Am. 1992; 72:157–182.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
9. Kidambi H, Herbert R, Kidambi AV. Ultrasonic demonstration of superior mesenteric and splenoportal venous thrombosis. J Clin Ultrasound. 1986; 14:199–201.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
10. Morasch MD, Ebaugh JL, Chiou AC, Matsumura JS, Pearce WH, Yao JS. Mesenteric venous thrombosis: a changing clinical entity. J Vasc Surg. 2001; 34:680–684.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
11. Rharrit D, Harmouche H, Baroudi S, et al. Protein C deficiency and mesenteric venous thrombosis. Can J Surg. 2009; 52:E35–37.
12. Condat B, Pessione F, Hillaire S, et al. Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy. Gastroenterology. 2001; 120:490–497.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
13. Cappell MS. Intestinal (mesenteric) vasculopathy. I. Acute superior mesenteric arteriopathy and venopathy. Gastroenterol Clin North Am. 1998; 27:783–825.
14. Rivitz SM, Geller SC, Hahn C, Waltman AC. Treatment of acute mesenteric venous thrombosis with transjugular intramesenteric urokinase infusion. J Vasc Interv Radiol. 1995; 6:219–223.
![crossref](/image/icon/bnr_ref_cross.gif)
![crossref](/image/icon/bnr_ref_cross.gif)
15. Nair V, Seth AK, Sridhar CM, Chaudhary R, Sharma A, Anand AC. Protein-c deficiency presenting with subacute intestinal obstruction due to mesenteric vein thrombosis. J Assoc Physicians India. 2007; 55:519–521.
Fig. 1.
Endoscopic findings of duodenum. (A) An oval shape ulcer with active bleeding was seen at the duodenal bulb. (B) Hemostasis was done using argon plasma coagulation.
![kjg-57-34f1.tif](/upload/SynapseXML/0028kjg/thumb/kjg-57-34f1.gif)
Fig. 2.
Contrast-enhanced abdominal CT findings. Intraluminal thrombus (arrow) was present in the dilated superior mesenteric vein. Bowel edema was not observed.
![kjg-57-34f2.tif](/upload/SynapseXML/0028kjg/thumb/kjg-57-34f2.gif)