A Case of Primary Mucoepidermoid Carcinoma Arising from the Common Bile Duct

Byeong Jun Song; Jung Hee Kwon; Jin Joo Kim; Jung Won Lee; Sun Young Min; Kyoung Bun Lee; Jin Young Jang; Ji Kon Ryu

doi:10.4166/kjg.2011.57.5.319

Journal List > Korean J Gastroenterol > v.57(5) > 1006813

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Song, Kwon, Kim, Lee, Min, Lee, Jang, and Ryu: A Case of Primary Mucoepidermoid Carcinoma Arising from the Common Bile Duct

Case Report

Korean J Gastroenterol 2011;57(5):319-322.

Published online: 4 October 2011

DOI: https://doi.org/10.4166/kjg.2011.57.5.319

A Case of Primary Mucoepidermoid Carcinoma Arising from the Common Bile Duct

Byeong Jun Song, Jung Hee Kwon, Jin Joo Kim, Jung Won Lee, Sun Young Min¹, Kyoung Bun Lee¹, Jin Young Jang², Ji Kon Ryu

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

¹Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

²Department of Surgery, Seoul National University College of Medicine, Seoul, Korea

Correspondence to: Ji Kon Ryu, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul 110-799, Korea. Tel: +82-2-2072-1962, Fax: +82-2-762-9662, E-mail: jkryu@snu.ac.kr

Received 10 September 201021 October 2010 Accepted 21 October 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mucoepidermoid carcinoma of the bile duct is an extremely rare tumor. Seventeen cases originating from intrahepatic bile duct and 2 cases from common hepatic duct have been reported in the English literature. Mucoepidermoid carcinoma arising from the common bile duct has not been previously reported. A 68 year-old man was admitted due to obstructive jaundice. Computed tomography showed a malignant tumor of the common bile duct located in the intrapancreatic segment. Filling defects of the distal common bile duct was seen on endoscopic retrograde cholangiogram. Under the impression of bile duct cancer, pylorus-preserving pancreatoduodenectomy was performed. Histologic diagnosis of the resected specimen was mucoepidermoid carcinoma of the common bile duct. After surgery, the patient received concurrent chemoradiotherapy, and planned to receive additional chemotherapy. We herein report on a first case of primary mucoepidermoid carcinoma of the common bile duct, and review the literature.

Keywords: Carcinoma, Mucoepidermoid, Common bile duct

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Fig. 1.

Abdominal CT findings. An intraluminal mass and bile duct dilatation were seen in the distal common bile duct.

Fig. 2.

Endoscopic retrograde cholangiographic findings. A filling defect was seen at the level of the distal common bile duct with bile duct the dilatation, and plastic stent was inserted.

Fig. 3.

Magnetic resonance cholangiopancreatographic findings. Diffuse dilatation of bile ducts was seen with filling defect at the distal common bile duct.

Fig. 4.

Resected specimen. Gross specimen showed polypoid mass at distal common bile duct.

Fig. 5.

Microscopic findings. (A) High power field view showed both squamous carcinomas (left side) and mucin producing carcinomas (right side) (H&E stain, ×400). (B) Nuclear staining of p16 protein in squamous carcinomas (immunohistochemistry, ×400).

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