KoreaMed Synapse

Journal List > Korean J Gastroenterol > v.56(1) > 1006759

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Song: Is 24 Weeks of Peginterferon and Ribavirin Combination Therapy Sufficient for the Patients with Genotype 1 Chronic Hepatitis C?

Editorial

Korean J Gastroenterol 2010;56(1):59-61.

Published online: 21 February 2010

DOI: https://doi.org/10.4166/kjg.2010.56.1.59

Is 24 Weeks of Peginterferon and Ribavirin Combination Therapy Sufficient for the Patients with Genotype 1 Chronic Hepatitis C?

Byung-Cheol Song, M.D.

Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea

Correspondence to: Byung-Cheol Song, M.D. Department of Internal Medicine, Jeju National University Hospital, 1753-3, Ara-dong, Jeju 690-716, Korea Tel: +82-64-717-1528, Fax: +82-64-717-1131 E-mail: drsong@jejunu.ac.kr

Copyright © 2010 The Korean Journal of Gastroenterology

REFERENCES

1. Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009; 49:1335–1374.

2. Shin HR. Epidemiology of hepatitis C virus in Korea. Intervirology. 2006; 49:18–22.

3. Strader DB, Wright T, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C. Hepatology. 2004; 39:1147–1171.

4. Lai CL, Gane E, Liaw YF, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med. 2007; 357:2576–2588.

5. Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005; 129:528–536.

6. Ferenci P, Brunner H, Laferl H, et al. A randomized, prospective trial of ribavirin 400 mg/day versus 800 mg/day in combination with peginterferon alfa-2a in hepatitis C virus genotypes 2 and 3. Hepatology. 2008; 47:1816–1823.

7. Yu ML, Dai CY, Huang JF, et al. Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients: a randomized trial. Hepatology. 2008; 47:1884–1893.

8. Zeuzem S, Buti M, Ferenci P, et al. Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J Hepatol. 2006; 44:97–103.

9. Moon SS, Kang HG, Seo JA, et al. 24 weeks treatment with pegylated interferon alfa plus ribavirin may be possible in genotype 1 chronic hepatitis C patients with rapid virological response who have low pretreatment viremia. Korean J Gastroenterol. 2010; 56:33–38.

10. Jensen DM, Morgan TR, Marcellin P, et al. Early identi-fication of HCV genotype 1 patients responding to 24 weeks peginterferon alpha-2a (40 kd)/ribavirin therapy. Hepatology. 2006; 43:954–960.

11. Lee CM, Hung CH, Lu SN, Changchien CS. Hepatitis C virus genotypes: clinical relevance and therapeutic implications. Chang Gung Med J. 2008; 31:16–25.

12. Zein NN. Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev. 2000; 13:223–235.

13. Zein NN, Rakela J, Krawitt EL, Reddy KR, Tominaga T, Persing DH. Hepatitis C virus genotypes in the United States: epidemiology, pathogenicity, and response to interferon therapy. Collaborative Study Group. Ann Intern Med. 1996; 125:634–639.

14. Ferenci P, Laferl H, Scherzer TM, et al. Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response. Gastroenterology. 2008; 135:451–458.

Table 1.

Summary of the Rate of Sustained Virological Response in Genotype 1 Chronic Hepatitis C Patients with Rapid Virological Response who Completed 24 or 48 Weeks of Therapy

Authors	HCV RNA levels	Sustained virological response (%)
Authors	HCV RNA levels	24 weeks of therapy	48 weeks of therapy
Zeuzem et al.⁸.	≤600,000 IU/mL	89%	85%
Ferenci et al.¹⁴.	≤400,000IU/mL	81.3%	Not available
	400,000-800,000 IU/mL	80.6%
	>800,000 IU/mL	66.7%
Yu et al.⁷.	≤400,000 IU/mL	96.4%	100%
	>400,000 IU/mL	76.5%	100%
Moon et al.⁹	>600,000 IU/mL	100%	96.2%

TOOLS

Similar articles