A Case of Psoriasis Induced by Infliximab Treatment for Crohn's Disease

Yoon Jung Jwa; Nam-Hoon Kim; Hai Jin Park; Jun Sup Park; Won Ki Bae; Kyung-Ah Kim; June Sung Lee; Young Soo Moon

doi:10.4166/kjg.2010.56.5.324

Journal List > Korean J Gastroenterol > v.56(5) > 1006738

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Jwa, Kim, Park, Park, Bae, Kim, Lee, and Moon: A Case of Psoriasis Induced by Infliximab Treatment for Crohn's Disease

Original Article

Korean J Gastroenterol 2010;56(5):324-328.

Published online: 21 February 2010

DOI: https://doi.org/10.4166/kjg.2010.56.5.324

A Case of Psoriasis Induced by Infliximab Treatment for Crohn's Disease

Yoon Jung Jwa, M.D., Nam-Hoon Kim, M.D., Hai Jin Park, M.D.^∗, Jun Sup Park, M.D., Won Ki Bae, M.D., Kyung-Ah Kim, M.D., June Sung Lee, M.D., Young Soo Moon, M.D.

Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

^∗Department of Dermatology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

Correspondence to: Nam-Hoon Kim, M.D. Department of Internal Medicine, Inje University Ilsan Paik Hospital, 2240, Daehwa-dong, Ilsan-seogu, Goyang 411-706, Korea Tel: +82-31-910-7200, Fax: +82-31-910-7219 E-mail: n-hkim@paik.ac.kr

Received 22 February 2010 Accepted 25 May 2010

Abstract

Infliximab, the monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn's disease and rheumatoid arthritis. Infliximab treatment has adverse events including infusion reactions, op-portunistic infections, and the potential for the event such as reactivation of latent tuberculosis. Cutaneous adverse reactions of TNF-α agents include skin rash, urticaria, pruritus, lupus-like eruption, and injection site reactions. Most of all, psoriasis or psoriasiform dermatitis induced by infliximab treatment for Crohn's disease is rarely reported in Korea. We report a case of psoriasis induced by infliximab treatment for Crohn's disease with a review of world literature.

Keywords: Crohn's disease, Infliximab, Psoriasis

REFERENCES

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Fig. 1.

Initial colonoscopic findings. (A) Perianal fistula was seen. (B, C) Longitudinal ulcers with cobble stone appearance were observed at the terminal ileum. (D) Another apthous ulcers were noted at the descending colon.

Fig. 2.

Photographs of the skin lesion. (A) Psoriasis with reddened skin and pustules was developed on the back. (B) After treatment, the skin lesion was completely healed, with no signs of discoloration or scarring.

Fig. 3.

Microscopic finding of the skin lesion. Hyperkeratosis, dermal papilla elongation, and perivascular lymphocytic infiltration were seen (H&E stain, ×100).

Fig. 4.

Post-infliximab treatment colonoscopic findings. (A) The closure of perianal fistula opening was noted. (B, C) Longitudinal ulcer scars with pseudopolyps were noted at the terminal ileum. (D) Ulcer scars with pseudopolyps were seen at the descending colon.

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