A Spongiform Mass in the Stomach: Pyloric Gland Adenoma with a Transition to Adenocarcinoma

Myueng Guen Oh; Soo-Jeong Cho; Jun Ho Lee; Myeong-Cherl Kook; Seog-Yun Park

doi:10.4166/kjg.2010.56.1.1

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Oh, Cho, Lee, Kook, and Park: A Spongiform Mass in the Stomach: Pyloric Gland Adenoma with a Transition to Adenocarcinoma

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Korean J Gastroenterol 2010;56(1):1-5.

Published online: 21 February 2010

DOI: https://doi.org/10.4166/kjg.2010.56.1.1

A Spongiform Mass in the Stomach: Pyloric Gland Adenoma with a Transition to Adenocarcinoma

Myueng Guen Oh, M.D., Soo-Jeong Cho, M.D., Jun Ho Lee, M.D., Myeong-Cherl Kook, M.D.^∗, Seog-Yun Park, M.D.^∗

Center for Gastric Cancer, National Cancer Center, Goyang, Korea

^∗Department of Pathology, National Cancer Center, Goyang, Korea

Correspondence to: Soo-Jeong Cho, M.D. Center for Gastric Cancer, National Cancer Center, 809, Madu 1-dong, Ilsandong-gu, Goyang 411-769, Korea Tel: +82-31-920-1604, Fax: +82-31-920-1289 E-mail: crystal522@ncc.re.kr

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Fig. 1.

Endoscopic findings. (A) About 3 cm sized polypoid mass sessile has been detected at gastric fundus. (B) The mass showed cri-briform or sponge-like surface full of tiny holes. Its surface appeared to be greasy with transparent mucus.

Fig. 2.

Abdominal CT showed a 3.5 cm sized polypoid mass with a short stalk in the gastric fundus. Lymph node involve-ment or distant metastasis was not observed.

Fig. 3.

Gross findings. (A) Polypoid lesion was detected at the resected stomach. (B) Polypoid mass was connected to the stomach by a short stalk with 1.5 cm sized base.

Fig. 4.

Microscopic findings. (A) Polypoid mass consisted of cystically dilated tubules which are not fused or irregularly branched (H&E stain, ×1). (B) Epithelial glands except gastric foveolar epithelum were strongly stained for MUC6 (×1). (C) Pyloric gland adenoma was composed of closely packed pyloric gland type tubules with a monolayer of cuboidal columnar epithelial cells containing pale to eosinophilic cytoplasm (white arrow). Pyloric gland adenocarcinoma had a nuclear atypism, ser-rated epithelial arrangement, and focal complex branching of tubules (black arrow) (H&E stain, ×100).

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