Abstract
Segmental colitis associated with diverticular disease (SCAD) is a colonic inflammatory disorder with localized non-granulomatous inflammation at sigmoid colon, and associated with colonic diverticulosis. SCAD is an appa-rently uncommon disorder in Western. We experienced a rare case of SCAD in a 46-year-old woman who visited the hospital due to abdominal discomfort. Colonoscopic examination showed multiple sigmoid diverticula in association with a segment length colitis. Colonoscopic biopsies of the sigmoid colon demonstrated cryptitis and crypt abscess along with chronic inflammatory cells infiltration. The biopsies of the rectum was histologically normal. The patient was given the diagnosis of SCAD and treated with oral mesalamine. This is the first case of SCAD reported in Korea.
REFERENCES
1. Imperiali G, Meucci G, Alvisi C, et al. Segmental colitis associated with diverticula: a prospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII). Am J Gastroenterol. 2000; 95:1014–1016.
2. Freeman HJ. Natural history and longterm clinical behavior of segmental colitis associated with diverticulosis (SCAD syndrome). Dig Dis Sci. 2008; 53:2452–2457.
3. Schmidt GT, Lennard-Jones JE, Morson BC, Young AC. Crohn's disease of the colon and its distinction from diverticulitis. Gut. 1968; 9:7–16.
5. Marshak RH, Janowitz HD, Present DH. Granulomatous colitis in association with diverticula. N Engl J Med. 1970; 283:1080–1084.
6. Makapugay LM, Dean PJ. Diverticular disease-associated chronic colitis. Am J Surg Pathol. 1996; 20:94–102.
7. Goldstein NS, Leon-Armin C, Mani A. Crohn's colitis-like changes in sigmoid diverticulitis specimens is usually an idio-syncratic inflammatory response to the diverticulosis rather than Crohn's colitis. Am J Surg Pathol. 2000; 24:668–675.
8. Burroughs SH, Bowrey DJ, Morris-Stiff GJ, Williams GT. Granulomatous inflammation in sigmoid diverticulitis: two disease or one? Histopathology. 1998; 33:349–353.
10. Pereira MC. Diverticular disease-asscociated colitis: progression to severe chronic ulcerative colitis after sigmoid surgery. Gastrointest Endosc. 1998; 48:520–523.
11. Lapidus A, Bernell O, Hellers G, Lö fberg R. Clinical course of colorectal Crohn's disease: a 35-year follow-up study of 507 patients. Gastroenterology. 1998; 114:1151–1160.
12. Berman IR, Coran ML, Coller JA, Veidenheimer MC. Late onset Crohn's disease in patients with colonic diverticulitis. Dis Colon Rectum. 1979; 22:524–529.
13. McCue J, Coppen MJ, Rasbridge SA, Lock MR. Coexistent Crohn's disease and sigmoid diverticulosis. Postgrad Med J. 1989; 65:636–639.
14. Peppercorn MA. Drug-responsive chronic segmental colitis associated with diverticula: a clinical syndrome in the elderly. Am J Gastroenterol. 1992; 87:609–612.
15. Sladen GE, Filipe MI. Is segmental colitis a complication of diverticular disease? Dis Colon Rectum. 1984; 27:513–514.