Treatment of Hepatitis B Virus Resistant to Lamivudine and Adefovir

Jin-Wook Kim

doi:10.4166/kjg.2009.53.5.329

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Kim: Treatment of Hepatitis B Virus Resistant to Lamivudine and Adefovir

Editorial

Korean J Gastroenterol 2009;53(5):329-330.

Published online: 21 February 2009

DOI: https://doi.org/10.4166/kjg.2009.53.5.329

Treatment of Hepatitis B Virus Resistant to Lamivudine and Adefovir

Jin-Wook Kim, M.D.

Department of Gastroenterology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

Correspondence to: Jin-Wook Kim, M.D. Department of Gastroenterology, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam 463-802, Korea Tel: +82-31-787-7009, Fax: +82-31-787-4051 E-mail: kimjw@snubh.org

REFERENCES

1. Lok AS, Lai CL, Leung N, et al. Longterm safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology. 2003; 125:1714–1722.

2. Lee KS, Kim DJ. Management of chronic hepatitis B. Korean J Hepatol. 2007; 13:447–488.

3. Rapti I, Dimou E, Mitsoula P, Hadziyannis SJ. Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B. Hepatology. 2007; 45:307–313.

4. Lampertico P, Vigano M, Manenti E, Iavarone M, Sablon E, Colombo M. Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. Gastroenterology. 2007; 133:1445–1451.

5. Suh HJ, Park MK, Lee HI, et al. Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis B patients with resistnace to lamivudine and adefovir consecutively. Korean J Gastroenterol. 2009; 53:305–310.

6. Kwon HC, Cheong JY, Cho SW, et al. Emergence of adefo-vir-resistant mutants after reversion to YMDD wild-type in lamivudine-resistant patients receiving adefovir monotherapy. J Gastroenterol Hepatol. 2009; 24:49–54.

7. Zaaijer HL, Takkenberg RB, Weegink CJ, et al. Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir. J Med Virol. 2009; 81:413–416.

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