Journal List > Korean J Cytopathol > v.19(2) > 1006527

Korean J Cytopathol. 2008 Sep;19(2):188-193. English.
Published online September 30, 2008.
Copyright © 2008 The Korean Society for Cytopathology
Imprint Cytology of Hepatic Angiomyolipoma -A Case Report-
Ae Ri Kim, M.D., Hong Jin Kim, M.D.,1 and Joon Hyuk Choi, M.D.
Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
1Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
Received July 17, 2008; Accepted August 29, 2008.


Angiomyolipoma of the liver is a rare benign tumor that's composed of variable mixtures of adipose tissue, smooth muscle and thick-walled blood vessels. We report here on the imprint cytologic features of a hepatic angiomyolipoma in a 47-year-old man. The smears showed spindle and epithelioid tumor cells in clusters, trabeculae and single cells. The spindle cells had elongated, cigar-shaped nuclei with finely granular chromatin and fibrillary cytoplasm. The epithelioid cells had round nuclei with a moderate amount of cytoplasm. Any adipose tissue was not found. Immunohistochemically, both the spindle and epithelioid cells revealed cytoplasmic positivity for smooth muscle actin and HMB-45.

Keywords: Angiomyolipoma; Liver; Cytology; Imprint


Fig. 1
Computed tomography of the liver. Computed tomography shows a well demarcated tumor with peripheral contrast enhancement (arrow).
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Fig. 2
Cytologic findings. (A) Spindle tumor cells have elongated, cigar-shaped nuclei with eosinophilic fibrillary cytoplasm and indistinct cell border (H&E). (B) Spindle tumor cells show naked nuclei with fine chromatin and small nucleoli (H&E). (C) Epithelioid tumor cells are arranged in solid nests (Papanicolaou stain). (D) Tumor cells are positive for smooth muscle actin (Immuohistochemical stain).
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Fig. 3
Gross finding. Tumor shows a well circumscribed gray-white solid cut surface.
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Fig. 4
Histologic findings. (A) Spindle tumor cells have elongated, cigar-shaped nuclei with eosinophilic cytoplasm (H&E). (B) Epithelioid tumor cells have round vesicular nuclei with pale or clear cytoplasm with trabecular arrangement (H&E). (C) Thick-walled blood vessels are present (H&E). (D) Epithelioid tumor cells show cytoplasmic positivity for HMB-45 (Immunohistochemical stain).
Click for larger image

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