Journal List > Korean J Cytopathol > v.19(2) > 1006525

Korean J Cytopathol. 2008 Sep;19(2):178-182. Korean.
Published online September 30, 2008.
Copyright © 2008 The Korean Society for Cytopathology
Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology in the Diagnosis of a Gastrointestinal Stromal Tumor of the Stomach -A Case Report-
Lucia Kim, M.D., Hyung Gil Kim, M.D.,1 Young Chae Chu, M.D., In Suh Park, M.D., Suk Jin Choi, M.D., Jee Young Han, M.D., Sun Hee Kim, M.D., Don Haeng Lee, M.D.,1 and Joon Mee Kim, M.D.
Department of Pathology, College of Medicine, Inha University, Incheon, Korea.
1Department of Gastroenterology, College of Medicine, Inha University, Incheon, Korea.
Received July 21, 2008; Accepted September 10, 2008.


We report here a case of a gastrointestinal stromal tumor (GIST) in the stomach that was diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNA). A 67 year old male patient underwent regular check-ups for five years due to the presence of a submucosal tumor that was found in the fundus of the stomach incidentally. EUS-FNA was performed to evaluate the tumor, which had increased in size from 1cm to 2.8cm. A cytologic smear revealed cohesive sheets or clusters of spindle cells with elongated nuclei. Immunohistochemical staining revealed a strong positive reaction for c-kit and CD34, without any reaction for smooth muscle actin and Ki-67. Therefore, a diagnosis of GIST was made.

Keywords: Gastrointestinal stromal tumor; Endoscopy; Ultrasound-guided fine needle aspiration cytology; Immunohistochemistry


Fig. 1
Tightly aggregated and loosely cohesive tumor cells present in clean background. The tumor cells are uniform and long spindling with ill-defined cytoplasmic border forming fascicular arrangement and nuclear palisading.(Papanicolaou stain).
Click for larger image

Fig. 2
The tumor cells show spindle cytoplasm with tapering both ends and bland looking elongated nuclei, fine chromatin, and inconspicuous nucleoli (Papanicolaou stain).
Click for larger image

Fig. 3
Immunohistochemical staining reveals diffuse strong positivity of tumor cells for c-kit(A) and CD34(B) without any reaction for SMA(C) and Ki-67(D) (Immunocytochemical stain).
Click for larger image

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