Journal List > Korean J Cytopathol > v.19(2) > 1006522

Korean J Cytopathol. 2008 Sep;19(2):164-167. Korean.
Published online September 30, 2008.
Copyright © 2008 The Korean Society for Cytopathology
Cytologic Findings of Malakoplakia of the Uterine Cervix and the Vagina -A Case Report-
Yi Kyeong Chun, M.D., Sung Ran Hong, M.D., Hye Sun Kim, M.D., Ji Young Kim, M.D., Bok Man Kim, C.T.(I.A.C.) and Hy Sook Kim, M.D.
Department of Pathology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
Received July 16, 2008; Accepted August 25, 2008.


Malakoplakia is an uncommon chronic granulomatous inflammation that usually involves the urinary and gastrointestinal tracts, but rarely affects the female genital tract. We experienced a case of malakoplakia in a cervicovaginal smear in a 54-year-old woman. Colposcopic examination showed a friable, easily bleeding tissue in the uterine cervix and the vaginal fornix. The cervicovaginal smear consisted of numerous isolated histiocytes, polymorphonuclear leukocytes, lymphocytes, and plasma cells. The histiocytes had an abundant, granular, and degenerated cytoplasm with inflammatory cell debris. Michaelis-Gutmann bodies were readily identified.

Keywords: Malakoplakia; Uterine cervix; Vagina; Cytology


Fig. 1
Colposcopic finding: friable, easily bleeding tissue in the uterine cervix and the vaginal fornix is noted.
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Fig. 2
Histologic findings (A) The cervical mucosa is covered by thick layers of inflammatory exudates forming plaque-like tissue. (B) The histiocytes (von Hansemann cells) have abundant, granular and degenerated cytoplasm with debris of inflammatory cells. (C) Numerous intracellular and extracellular calcified inclusions (Michaelis-Gutmann bodies) are noted (arrows). (H&E).
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Fig. 3
Cytologic features on cervicovaginal smear (A) Numerous isolated histiocytes (von Hansemann cells), polymorphonuclear leukocytes, lymphocytes, and plasma cells are seen. (B) Laminated intracellular Michaelis-Gutmann bodies (arrows) are identified. (Papanicolaou stain).
Click for larger image

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