Journal List > Korean J Cytopathol > v.19(2) > 1006515

Korean J Cytopathol. 2008 Sep;19(2):119-125. Korean.
Published online September 30, 2008.
Copyright © 2008 The Korean Society for Cytopathology
Comparison of Clinical Efficacy between an HPV DNA Chip and a Hybrid-Capture II Assay in a Patient with Abnormal Colposcopic Findings
Tae-Jung Kim, M.D., Chan Kwon Jung, M.D., Ahwon Lee, M.D., Eun Sun Jung, M.D., Young Jin Choi, M.D., Kyo Young Lee, M.D. and Jong Sup Park, M.D.1
Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Received July 21, 2008; Accepted September 04, 2008.


This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.

Keywords: HPV; HC-II; HPV DNA chip


Fig. 1
The comparison of HPV type and histologic results.
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Table 1
The distribution of HPV genotypes by HPV DNA chip test according to histologic results
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Table 2
Histologic results related to result of cytology and HPV test
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Table 3
Clinical usefulness of cytology and HPV test
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Table 4
Clinical usefulness of HPV test combined with cytology
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Table 5
Comparison between HC-II and DNA chip in cases more than koilocytosis
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