Journal List > Korean J Obstet Gynecol > v.53(10) > 1006482

Lim, Kim, Park, Chung, Park, Song, and Kang: The efficacy of a real-time optoelectronic device as a diagnostic tool of over cervical intraepithelial neoplasia 1 lesion



The purpose of this study was to evaluate the sensitivity, specificity and accuracy of a real-time optoelectronic device (TruScreen) as a diagnostic tool of cervical intraepithelial neoplasia (CIN) or cervical cancer.


Two hundred ninety two patients who had been presented with previously abnormal Papanicolaou (Pap) smear or abnormal colposcopic findings between February 2009 and September 2009 were analyzed. The sensitivities, specificities and accuracies of TruScreen and liquid-based cytology were evaluated.


As a diagnostic tool of CIN, carcinoma in situ (CIS), and cervical cancer, TruScreen appeared sensitive enough compared with liquid-based cytology (82.8% vs 75.9%), but the difference is statistically not significant (P=0.687). Specificity and accuracy of TruScreen were similar to those of liquid-based cytology (specificity 81.4% vs 83.3%, accuracy 81.5% vs 82.5%).


The present study suggests that the TruScreen could be an option as a tool of screening test in CIN, CIS, and cervical cancer and also be used combined with Pap smear.

Figures and Tables

Fig. 1
The appearance of TruScreen which consists of a console and a probe.
Table 1
Chracteristics of 292 women

HPV: human papillomavirus, CIN: cervical intraepithelial neoplasia, CIS: carcinoma in situ.

Table 2
Liquid-based cytology concordance with cervical pathology

CIN: cervical intraepithelial neoplasia.

Table 3
TruScreen concordance with cervical pathology

CIN: cervical intraepithelial neoplasia.

Table 4
LBC combined TruScreen concordance with cervical pathology

LBC: liquid-based cytology, CIN: cervical intraepithelial neoplasia.

Table 5
HPV hybridcapture concordance with cervical pathology

HPV: human papillomavirus, CIN: cervical intraepithelial neoplasia.

Table 6
HPV hybridcapture combined TruScreen concordance with cervical pathology

HPV: human papillomavirus, CIN: cervical intraepithelial neoplasia.

Table 7
Sensitivities, specificities and accuracies of LBC, TruScreen, and combined LBC+TruScreen

LBC: liquid-based cytology, CI: confidence interval.

*P=0.687, P=0.630.


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