Journal List > Korean J Obstet Gynecol > v.53(12) > 1006376

Korean J Obstet Gynecol. 2010 Dec;53(12):1124-1128. Korean.
Published online December 21, 2010.
Copyright © 2010 Korean Society of Obstetrics and Gynecology
Two cases of immature teratoma
Ji-Hyun Kim, M.D., A-Ra Ko, M.D., Kyung-Hee Lee, M.D., Yoon-A Jung, M.D., Sung-Joo Kim, M.D., Young-Han Park, M.D., Jung-Bae Kang, M.D., Pong-Rheem Jang, M.D. and Chae-Chun Rhim, M.D.
Department of Obstetrics and Gynecology, Hallym University College of Medicine, Chuncheon, Korea.

Corresponding author (Email: )
Received September 27, 2010; Revised November 05, 2010; Accepted December 01, 2010.


About 20~30% of benign or malignant tumors of ovarian origin arise from embryonic cells, and only 3% represent malignancy. But under age of 20, 70% of ovarian tumors arise from embryonic cells, and over 1/3 of them are malignant tumors. Over all the ovarian tumors arising from embryonic cells, immature teratoma is germ cell tumor, components include immature tissues and cells derived from ectoderm, mesoderm, and endomermal origins. Most of the immature tissues are from neuroectodermal origins. The immature teratoma of the ovary is a rare tumor, representing less than 1% of all ovarian neoplasm. These tumors typically present in young age woman (mean age 10~20 years) with pelvic and abdominal pain. Nowadays newly developed combination chemotherapeutic agents such as bleomycin, etoposide, cisplatin give us great survival and disease free prognosis than before. We have experienced two cases of immature teratoma so we report them with a brief review of concerned literatures.

Keywords: Immature teratoma; Ovary


Fig. 1
On pelvis magnetic resonance imaging, there is about 20×10×18 cm sized large cystic and solid component possesing fatty mass.
Click for larger image

Fig. 2
The resected ovary. The external capsule of ovarian mass is smooth and glistening. The mass in predominantly solid, fleshy, and gray-tan cystic with mucinous fluid.
Click for larger image

Fig. 3
Immature teratoma of the ovary illustrated promitive neuroepithelium (H&E stain, ×100).
Click for larger image

Fig. 4
On pelvis magnetic resonance imaging, there is about 15×10×20 cm sized large lobulated mass, mostly solid component. It shows numerous internal cacification.
Click for larger image

Fig. 5
The cut off external surface is gray-tan and multinodular and inside, multifocal hemorrhagic necrotic foci was observed. Many calcified materials.
Click for larger image

Fig. 6
Immature goblet cells and neuroepithelium was seen (H&E stain, ×40).
Click for larger image

1. Scully RE, Young RH, Clement PB. In: Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament: atlas of tumor pathology (Afip atlas of tumor pathology No. 23). Washington: Armed Forces Institute of Pathology; 1998.
2. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer 1976;37:2359–2372.
3. Taylor CW, Haines M, Fox H. In: Haines and Taylor obstetrical and gynecological pathology. 3rd ed. Edinburgh: Churchill Livingstone; 1987.
4. Curry SL, Smith JP, Gallagher HS. Malignant teratoma of the ovary: prognostic factors and treament. Am J Obstet Gynecol 1978;131:845–849.
5. Nogales FF Jr, Ortega I, Rivera F, Armas JR. Metanephrogenic tissue in immature ovarian teratoma. Am J Surg Pathol 1980;4:297–299.
6. Kawai M, Furuhashi Y, Kano T, Misawa T, Nakashima N, Hattori S, et al. Alpha-fetoprotein in malignant germ cell tumors of the ovary. Gynecol Oncol 1990;39:160–166.
7. Berek JS, Fu YS, Hacker NF. Ovarian cancer. In: Berek JS, Adashi EY, Hillard PA, editors. Novak's Gynecology. 12th ed. Baltimore: Williams & Wilkins; 1996. pp. 1201.
8. Robboy SJ, Scully RE. Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum Pathol 1970;1:643–653.
9. Fortt RW, Mathie IK. Gliomatosis perionei caused by ovarian teratoma. J Clin Pathol 1969;22:348–353.
10. Norris HT, O'Conner DM. Pathology of malignant germ cell tumors of the ovary. In: Coppleson M, editor. Gynecologic oncology. 2nd ed. New York: Churchill Livingston; 1992. pp. 917-934.
11. Slayton RE. Management of germ cell and stromal tumors of the ovary. Semin Oncol 1984;11:299–313.
12. Kawai M, Kano T. Seven tumor markers in benign and malignant germ cell tumors of the ovary. Gynecol Oncol 1992;45:248–253.
13. Jung MH, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH, et al. Clinical anapysis of 24 cases of immature teratoma of the ovary. Korean J Obstet Gynecol 2005;48:2926–2931.