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Abstract
Purpose
Transrectal ultrasonography (TRUS)-guided prostate biopsy causes fear and pain in 65% to 90% of patients. This study was designed to evaluated the use of intravenous propofol anesthesia during TRUS-guided prostate biopsy.
Materials and Methods
Between January 2006 and June 2008, 195 men undergoing a transrectal prostate biopsy were divided into 2 groups according to anesthetic technique. Group A consisted of 99 patients who received intravenous propofol infusion through an 18 gauge needle during TRUS-guided prostate biopsy. Group B consisted of 96 patients who intrarectally received 10 ml of 2% lidocaine gel 10 minutes before TRUS-guided prostate biopsy. Pain scores were assessed on a visual analogue scale immediately after prostate biopsy.
Results
The pain score was significantly reduced in group A compared with group B. There was a significant difference in the mean pain score between the 2 groups (1.0±1.3 in group A versus 2.9±2.0 in group B; p< 0.01). Also, there was a significant difference in the willingness to undergo rebiopsy between the 2 groups (83.8% in group A versus 17.7% in group B; p<0.01). However, the complication rates were not significantly different between the 2 groups. Gross hematuria was found in 14% of group A patients and 18% of group B patients.
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Fig. 1.
Individual pain assessment by category. Group A: intravenous propofol, Group B: intrarectal lidocaine gel.
Table 1.
Characteristics of the patients
| Group A | Group B | p-value | |
|---|---|---|---|
| No. of patients | 99 | 96 | |
| Age (years) | 67.3±9.1 | 67.8±10.4 | 0.855 |
| PSA (ng/ml) | 14.0±23.2 | 13.9±21.6 | 0.979 |
| Prostate volume (ml) | 62.7±23.1 | 63.1±27.2 | 0.910 |
Table 2.
Comparison of results between groups and willingness to undergo prostate rebiopsy
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