Journal List > Korean J Urol > v.50(2) > 1005284

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Kim, Cho, Han, Joung, Seo, Chung, Pak, Park, and Lee: Familial Prostate Cancer in Three Brothers
Case Report
Korean Journal of Urology

Korean Journal of Urology 2009; 50(2): 195-198.

Published online: 25 February 2009

DOI: https://doi.org/10.4111/kju.2009.50.2.195

Familial Prostate Cancer in Three Brothers

Sung Han Kim1, Kang Su Cho, Kyung Seok Han, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Hee Ok Pak2, Weon Seo Park3, Kang Hyun Lee

Urologic Oncology Clinic, National Cancer Center, Goyang, Korea.

1Department of Urology, Seoul National University College of Medicine, Seoul, Korea.

2Gachon University of Medicine and Science, Incheon, Korea.

3Department of Pathology, National Cancer Center, Goyang, Korea.

Correspondence to: Kang Hyun Lee. Urologic Oncology Clinic, National Cancer Center, 111, Jungbalsan-ro, Ilsandong-gu, Goyang 410-769, Korea. TEL: 031-920-1505, FAX: 031-920-1520, uroonco@ncc.re.kr

Received 24 July 2008       Accepted 13 October 2008

Copyright © The Korean Urological Association, 2009

Abstract

We treated a family of 3 brothers with prostate cancer, which is the first report of familial prostate cancer in Korea. Prostate cancer was diagnosed in the first brother with a prostate-specific antigen (PSA) level of 12.70 ng/ml of at the age of 68 years. He underwent a radical retropubic prostatectomy (RRP); the cancer was pathologically staged to T2cN1Mo. He received adjuvant hormonal therapy postoperatively. Three years later, prostate cancer was diagnosed in the third brother at the age of 61 years with a high PSA level of 4.45 ng/ml. He underwent RRP, which revealed the pathological stage to be T2cN0M0. Three months later, the second brother, who had visited our hospital for lower urinary tract symptoms and for a PSA screening test was diagnosed with prostate cancer at the age of 60 years (PSA level of 3.96 ng/ml). He also underwent RRP, and his cancer was staged pathologically as T2cN0M0.

Keywords: Prostatic neoplasms, Siblings

Figures and Tables

Fig. 1
Three brothers' familial pedigree.
kju-50-195-g001
Table 1
Patients' characteristics
kju-50-195-i001

PMHx: past medical history, DM: diabetes mellitus, BPH: benign prostatic hyperplasia, HTN: hypertension, PSA: prostatic specificantigen, GS: Gleason score, RP: radical prostatectomy, BCR: biochemical recurrence, HT: adjuvant, F/U: follow-up duration

Table 2
Molecular genetic analysis of BRCA2 gene mutation by PCR and direct sezuencing in genomic DNA isolated from peripheral blood leukocytes
kju-50-195-i002

a: observed genetic variations of exons of among 28 exons of BRCA2 gene (chromosome 13q12.3), PCR: polymerase chain reaction

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