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Yoon, Jeong, Lee, and Kim: Effect of Tamsulosin and Dichlozid on the Expected Treatment of Ureteral Calculi
Original Article
Endourology/Urolithiasis
Korean Journal of Urology

Korean Journal of Urology 2009; 50(12): 1213-1218.

Published online: 18 December 2009

DOI: https://doi.org/10.4111/kju.2009.50.12.1213

Effect of Tamsulosin and Dichlozid on the Expected Treatment of Ureteral Calculi

Woon Yong Yoon, Tae Yoong Jeong, Sang Ik Lee, Dong Jun Kim

Department of Urology, College of Medicine, Kwandong University, Goyang, Korea.

Correspondence to: Dong Jun Kim. Department of Urology, Myongji Hospital, College of Medicine, Kwandong University, 697-24, Hwajeong-dong, Deogyang-gu, Goyang 412-270, Korea. TEL: 031-810-6150, FAX: 031-810-5109, urokdj@hotmail.com

Received 1 October 2009       Accepted 2 December 2009

Copyright © The Korean Urological Association, 2009

Abstract

Purpose

We evaluated the effect of tamsulosin and hydrochlorothiazide (Dichlozid) on the expulsion of ureteral stones.

Materials and Methods

A total of 132 patients with a single ureteral calculi less than 10 mm in diameter were enrolled and divided into 3 groups: group 1 (n=40) received tamsulosin (0.2 mg/day), group 2 (n=35) received Dichlozid (25 mg/day) and tamsulosin (0.2 mg/day), and group 3 (n=57) was the control. Proximal and distal ureteral stones were evaluated separately. Efficacy was evaluated in terms of the rate and duration of expulsion according to stone size (<5 mm, ≥5 mm) for a maximum period of 4 weeks.

Results

The mean stone diameters were 4.9±1.7 mm (group 1), 4.8±1.6 mm (group 2), and 5.3±1.8 mm (group 3). The overall expulsion rates were 70%, 74.3%, and 52.6%, respectively, and showed statistical significance. The mean durations of expulsion were 14.7±1.6, 12.8±1.5, and 18.0±2.0 days, respectively, and group 2 showed a significant decrease in the duration. There were no significant differences in the expulsion rate of proximal and distal ureteral stones in any group. Distal ureteral stones in groups 1 and 2 showed a significant reduction in the mean expulsion time (<5 mm: 13.6±0.5, 11.8±0.7, and 16.7±0.8 days in groups 1, 2, and 3, respectively; ≥5 mm: 15.0±1.4, 13.0±0.6, and 17.8±0.4 days in groups 1, 2, and 3, respectively). The mean expulsion time for smaller proximal stones (<5 mm) in groups 1 and 2 was reduced significantly (17±0.6, 15.2±0.8, and 19.3±0.6 days in groups 1, 2, and 3, respectively).

Conclusions

Medical therapy with tamsulosin is time-saving and effective for treating ureteral calculi. In addition, adjunctive treatment with Dichlozid may reduce the duration of expulsion.

Keywords: Ureteral calculi, Tamsulosin, Diuretics

Figures and Tables

Fig. 1
Difference in duration of passage between Group 1 (tamsulosin) and Group 2 (tamsulosin+dichlozid). *: p<0.05 (proximal <5 mm: p=0.003, distal <5 mm: p<0.001, distal ≥ 5mm: p=0.009, distal total: p<0.001).
kju-50-1213-g001
Fig. 2
Difference in spontaneous passage rate between Group 1 (tamsulosin) and Group 2 (tamsulosin+dichlozid). No significant difference (p>0.05).
kju-50-1213-g002
Table 1
Comparison of patient characteristics
kju-50-1213-i001

Group 1: tamsulosin, Group 2: tamsulosin+dichlozid, Group 3: control, a: ANOVA, b: chi-square test

Table 2
Comparison of results according to the size and location of stones
kju-50-1213-i002

Group 1: tamsulosin, Group 2: tamsulosin+dichlozid, Group 3: control, a: chi-square test, b: Fisher's exact test, c: ANOVA

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