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Lee, Han, Jeong, and Rim: The Utility of Amitryptiline in Female Overactive Bladder Patients with Nocturia
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(8): 733-738.

Published online: 31 August 2008

DOI: https://doi.org/10.4111/kju.2008.49.8.733

The Utility of Amitryptiline in Female Overactive Bladder Patients with Nocturia

Jea Whan Lee, Dong Youp Han, Hee Jong Jeong, Joung Sik Rim

Department of Urology, Wonkwang University School of Medicine, Iksan, Korea.

uro94c@wonkwang.ac.kr

Received 12 November 2007       Accepted 12 June 2008

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

Anticholinergics suppress the muscarinic receptors in the bladder smooth muscle and, increase the level of urine storage. Their side effects include dry mouth, dry eyes, constipation, drowsiness, and tachycardia. These adverse effects limit the dosing and often decrease patient compliance. This study examined the effect of amitryptline as one of the first-line treatments for overactive bladder patients with nocturia.

Materials and Methods

Between June 2005 and June 2006, a prospective randomized study was carried out on 45 female patients with an overactive bladder. The mean age was 57.6 years and the patients were treated with doxazosin (Group I), doxazosin with tolterodine (Group II), doxazosin with amitriptyline (Group III). All 45 (Group I: 15, Group II: 15, Group III: 15) were followed up for 4 weeks. The treatment efficacy was measured using the 3 days of voiding diaries.

Results

The actual number diurnal voids showed considerable improvement after treatment (p<0.05). However, there was no difference in treatment results between Groups II and III (p>0.05). The actual number of nightly voids improved after treatment (p<0.05), but there was no change in Group I. There was no difference between Groups II and III (p>0.05). There was no difference in the total voiding volume, functional bladder capacity, nocturnal bladder capacity index, nocturia index between pre-treatment and post-treatment in each group (p>0.05).

Conclusions

There are some enhanced effects with the actual number of diurnal voids and the actual number nightly voids in patients treated with doxazosin with amitriptyline. Therefore, amitripyline is helpful as a first-line treatment in female overactive bladder patients with nocturia.

Keywords: Nocturia, Tricyclic antidepressant, Overactive bladder

Figures and Tables

Fig. 1
Comparison of the nocturnal frequency between each group. Note the significant improvement in groups II and III (p=0.005, p=0.002) and the similarity between groups II and III (p=0.101). *: p=0.669, †: p=0.001, by Kruskall-Wallis test.
kju-49-733-g001
Table 1
Definitions in the classification and etiology of nocturia
kju-49-733-i001
Table 2
Characteristics and symptoms of patients before treatment
kju-49-733-i002

by Kruskall-Wallis test, IPSS: International Prostate Symptom Score

Table 3
Comparison of the urine volume and voiding frequency between the pre- and post-treatment in each groups
kju-49-733-i003

*: by Wilcoxon signed rank test

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