Journal List > Korean J Urol > v.49(1) > 1005108

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Han, Kim, Park, and Yang: Comparison of the Intraparenchymal Biocompatibility of Oxidized Regenerated Cellulose and Porcine Small Intestine Submucosa in Rat Kidney
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(1): 43-48.

Published online: 31 January 2008

DOI: https://doi.org/10.4111/kju.2008.49.1.43

Comparison of the Intraparenchymal Biocompatibility of Oxidized Regenerated Cellulose and Porcine Small Intestine Submucosa in Rat Kidney

Woong Kyu Han, Se Hoon Kim1, Jong Pil Park1, Seung Choul Yang

Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

syang313@yumc.yonsei.ac.kr

Received 24 July 2007       Accepted 25 October 2007

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

The objective of this study was to evaluate the biological properties of a variety of materials that could be used in partial nephrectomy.

Materials and Methods

54 Sprague-Dawley rats (9 for each group) divided into an experimental period of 4 and 12 weeks, respectively. 2 other groups were the negative control for this experiment. We inserted oxidized regenerated cellulose and porcine small intestine submucosa into the defected renal parenchyme in the experimental groups. At the end of the observation periods, the animals were killed and their specimens prepared for histological examination to evaluate the different materials biocompatibility.

Results

The reaction of the tissue to the materials diminished with time. After analyzing both periods, the inflammatory reactions to oxidized regenerated cellulose and porcine small intestine submucosa were considered slight. There were no significant differences between oxidized regenerated cellulose and porcine small intestine submucosa. Oxidized regenerated cellulose and porcine small intestine submucosa showed biocompatibility in this test model at both time periods.

Conclusions

It was concluded that there was no difference of biocompatibility between oxidized regenerated cellulose and porcine small intestine submucosa. Both materials are safe, biocompatible materials that can be inserted into the renal parenchyma.

Keywords: Biocompatibility, Kidney, Rats

Figures and Tables

Fig. 1
Microscopic findings of the kidney section: note the slight inflammatory reaction. (A) 4 weeks after implantation of Surgicel® (×200), (B) 4 weeks after implantation of SIS (×200), (C) 12 weeks after implantation of Surgicel® (×200), (D) 12 weeks after implantation of SIS (×200).
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Fig. 2
Microscopic findings of the kidney section: note the moderate inflammatory reaction. (A) 4 weeks after implantation of Surgicel® (×200), (B) 4 weeks after implantation of SIS (×200), (C) 12 weeks after implantation of Surgicel® (×200), (D) 12 weeks after implantation of SIS (×200).
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Table 1
Number of renal units and the intensity of the inflammatory response
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Table 2
Histological evaluations of the tested materials at 4 and 12 weeks
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*Absent/slight, **moderate, ***severe

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