Journal List > Korean J Urol > v.49(3) > 1005081

Lee, Lee, Kim, Yoon, Kim, Yoo, and Kim: Primary Neuroendocrine Carcinoma of the Urethra

Abstract

Primary neuroendocrine carcinomas are uncommon highly malignant tumors of the genitourinary tract, and they have a poor prognosis. We report here on a case of a primary neuroendocrine carcinoma of the urethra that developed after radical cystectomy and ileal conduit diversion for treating transitional cell carcinoma of the urinary bladder.

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Fig. 1.
The computed tomography scan shows a 4x2.5cm sized well-demarcated cystic mass on the urethra.
kju-49-284f1.tif
Fig. 2.
(A) The tumor cells display a small, round to oval nucleus with scanty cytoplasm and hyperchromatic nuclei (H&E, x200). (B) The malignant cells show strong positive staining for chromogranin (Immunohistochemistry, x100). (C) The malignant cells show strong positive staining for cytokeratin (Immunohistochemistry, x100). (D) The malignant cells show strong positive staining for synaptophysin (Immunohistochemistry, x100).
kju-49-284f2.tif
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