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Kim, Kim, Namgoong, Park, Park, Lee, Lee, Chung, and The Korean Enuresis Association: A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(2): 168-173.

Published online: 29 February 2008

DOI: https://doi.org/10.4111/kju.2008.49.2.168

A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis

Jun Mo Kim, Young Sig Kim1, Mee Kyung Namgoong2, Kwan Hyun Park3, Yong Hoon Park4, Sang Don Lee5, Seung Joo Lee6, Jae Yong Chung7; The Korean Enuresis Association

Department of Urology, College of Medicine, Soonchunhyang University, Bucheon, Korea.

1Department of Urology, Ilsan Hospital, Ilsan, Korea.

2Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea.

3Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea.

4Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.

5Department of Urology, Pusan National University College of Medicine, Busan, Korea.

6Department of Pediatrics, Ewha Womans University College of Medicine, Korea.

7Department of Urology, College of Medicine, Inje University, Seoul, Korea.

urojun@schbc.ac.kr

Received 19 October 2007       Accepted 27 November 2007

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis (NE).

Materials and Methods

The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1 (imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2 (desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data.

Results

Mean wetting events in group 1 decreased from 8.8 to 5.1 times (2 weeks) and 3.0 times (4 weeks) (p=0.009) versus 10.2 to 5.5 times (2 weeks) and 6.4 times (4 weeks) (p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9 (baseline), 4.4 (2 weeks), and 3.7 (4 weeks), and, for group 2, 5.1 (baseline), 4.8 (2 weeks), and 4.8 (4 weeks). The two groups were not different (p=0.14, p=0.73).

Conclusions

Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.

Keywords: Nocturnal enuresis, Arousal, Imipramine, Deamino arginine vasopressin

Figures and Tables

Fig. 1
Sleeping patterns of patients. (A) Duration of sleeping time, (B) Bed time, (C) Time to wake up.
kju-49-168-g001
Table 1
Questionnaire for assessing arousal from sleep
kju-49-168-i001
Table 2
Changes in the number of wetting events and the threshold of arousability
kju-49-168-i002

Group 1: imipramine, Group 2: desmopressin. *Kruskal-Wallace test, †ANOVA

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