Journal List > Korean J Urol > v.49(2) > 1005054

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Choi, Ahn, Han, and Jang: The Effect of Tamsulosin and Nifedipine on Expulsion of Ureteral Stones after Extracorporeal Shock Wave Lithotripsy
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(2): 150-154.

Published online: 29 February 2008

DOI: https://doi.org/10.4111/kju.2008.49.2.150

The Effect of Tamsulosin and Nifedipine on Expulsion of Ureteral Stones after Extracorporeal Shock Wave Lithotripsy

Nak-Young Choi, Seung-Hyun Ahn, Jun-Hyun Han, In-Ho Jang

Department of Urology, KEPCO Medical Foundation Hanil General Hospital, Seoul, Korea.

uroahn@dreamwiz.com

Received 4 January 2008       Accepted 15 January 2008

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

We evaluated the effect of tamsulosin and nifedipine on expulsion of ureteral stones after extracorporeal shock wave lithotripsy (ESWL).

Materials and Methods

We evaluated 96 upper or lower ureteral stone patients. All patients received a single session of ESWL with a piezolith-3000 and received twice-a-day oral treatment of 5mg trospium chloride. The patients were randomly divided into three groups. Group 1 received once a day oral therapy of 0.2mg tamsulosin. Group 2 received once a day oral therapy of 30mg nifedipine. Group 3 was used as the control group. All patients took oral medication for 2 weeks, and then we analyzed the stone expulsion rate, side effects, and mean numbers of emergency room (ER) visits for pain control.

Results

There were no differences in the 3 groups in stone size, location, age, and sex. The total stone expulsion rate was significantly higher in group 1 (84.4%) compared with group 3 (60.6%) (p=0.032). Patients with lower ureteral stones in group 1 showed a higher expulsion rate (94.1%) than those of group 3 (66.7%) (p=0.042). There was no difference in stone expulsion rates between group 2 (67.7%) and group 3 (60.6%).

Conclusions

These result suggest that adjunctive medical therapy with tamsulosin after an ESWL increased the stone expulsion rate of ureteral stones, especially lower ureteral stones.

Keywords: Ureteral stones, Extracorporeal shockwave lithotripsy, Tamsulosin, Nifedipine

Figures and Tables

Table 1
Patient characteristics at baseline
kju-49-150-i001

*SD: standard deviation

Table 2
Success rate at 2 weeks after extracorporeal shock wave lithotripsy
kju-49-150-i002

Upper: Group 1 vs. Group 2 (p=0.597), Group 1 vs. Group 3 (p=0.456), Group 2 vs. Group 3 (p=0.837). Lower: Group 1 vs. Group 2 (p=0.146), Group 1 vs. Group 3 (p=0.042), Group 2 vs. Group 3 (p=0.521). Total: Group 1 vs. Group 2 (p=0.121), Group 1 vs. Group 3 (p=0.032), Group 2 vs. Group 3 (p=0.552)

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