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Sung, Jeon, and Chang: The Effect of the Serum Cholesterol Level on the Clinicopathologic Characteristics of Prostate Cancer
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(2): 127-133.

Published online: 29 February 2008

DOI: https://doi.org/10.4111/kju.2008.49.2.127

The Effect of the Serum Cholesterol Level on the Clinicopathologic Characteristics of Prostate Cancer

Wooseuk Sung, Seung Hyun Jeon, Sung-Goo Chang

Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea.

sgchang@khu.ac.kr

Received 5 October 2007       Accepted 4 December 2007

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

We assessed the relationship between the serum cholesterol level and the clinicopathologic characteristics of prostate cancer patients who had undergone a radical retropubic prostatectomy.

Materials and Methods

We enrolled 70 prostate cancer patients who had relevant data available for this study. All of the patients had their serum cholesterol level checked at least three times for a month preoperatively. We divided them into three groups according to: 1) a mean preoperative cholesterol level less than 180mg/dl, 2) between 180mg/dl and 200mg/dl, and 3) more than 200mg/dl. The serum cholesterol levels and other clinicopathologic characteristics were then compared and analyzed. The clinicopathologic findings included the pathologic T stage, Gleason score, prostate-specific antigen (PSA) and the other pathologic findings that included perineural invasion, vascular invasion, lymphatic invasion and capsular invasion. All the data was retrospectively collected from the patients' medical records.

Results

The mean cholesterol level was 181.1±4.1mg/dl. There was a statistically significant difference in the incidence of perineural invasion among these three groups according to the cholesterol level, with linear correlation (p=0.015). This correlation was more significant among the T2 patients or the patients with a total PSA value of 4ng/dl to 10ng/dl. Furthermore, the preoperative serum cholesterol level was significantly affected by the pathologic finding of perineural invasion (p=0.024, odd ratio=3.565).

Conclusions

There was a direct correlation between the increase incidence of perineural invasion with the increased preoperative serum cholesterol level for prostate cancer patients who had undergone radical prostatectomy.

Keywords: Prostatic cancer, Cholesterol, Prostatectomy

Figures and Tables

Table 1
Clinicopathologic characteristics of the patients according to the cholesterol level
kju-49-127-i001

PSA: prostate-specific antigen, Mean±standard deviation, using ANOVA and chi-square test, *: statistically significant but with chi-square test, but not with linear by linear association,†: statistically significant with chi-square test and linear by linear association

Table 2
Clinicopathologic characteristics of the patients according to the cholesterol level and pathologic T stage
kju-49-127-i002

PSA: prostate-specific antigen, *: statistically significant with chi-square analysis and linear by linear association

Table 3
Clinicopathologic characteristics of the patients according to the cholesterol level and total PSA level
kju-49-127-i003

PSA: prostate-specific antigen, *: statistically significant with chi-square analysis and linear by linear association

Table 4
Clinicopathologic characteristics of the patients according to the cholesterol level and Gleason score
kju-49-127-i004

PSA: prostate-specific antigen, *: statistically significant with chi-square analysis and linear by linear association

Table 5
Multivariate analysis of the effect of serum cholesterol on the clinicopathologic characteristics of patients who underwent RRP due to CaP
kju-49-127-i005

RRP: radical retropubic prostatectomy, CaP: prostatic cancer, PSA: prostate-specific antigen, OR: odd ratio, CI: confidence interval, *: statistically significant with multivariate logical regression test

References

1. Cook LS, Goldoft M, Schwartz SM, Weiss NS. Incidence of adenocarcinoma of the prostate in Asian immigrants to the United States and their descendants. J Urol. 1999. 161:152–155.
2. De Stefani E, Mendilaharsu M, Deneo-Pellegrini H, Ronco A. Influence of dietary levels of fat, cholesterol, and calcium on colorectal cancer. Nutr Cancer. 1997. 29:83–89.
3. Horn-Ross PL, Morrow M, Ljung BM. Diet and the risk of salivary gland cancer. Am J Epidemiol. 1997. 146:171–176.
4. Jarvinen R, Knekt P, Hakulinen T, Rissanen H, Heliovaara M. Dietary fat, cholesterol and colorectal cancer in a prospective study. Br J Cancer. 2001. 85:357–361.
5. Kaplan S, Novikov I, Modan B. Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat, and cholesterol. Am J Epidemiol. 1997. 146:832–841.
6. Wu Y, Zheng W, Sellers TA, Kushi LH, Bostick RM, Potter JD. Dietary cholesterol, fat, and lung cancer incidence among older women: the Iowa Women's Health Study (United States). Cancer Causes Control. 1994. 5:395–400.
7. Veierod MB, Laake P, Thelle DS. Dietary fat intake and risk of lung cancer: a prospective study of 51,452 Norwegian men and women. Eur J Cancer Prev. 1997. 6:540–549.
8. Chen H, Ward MH, Tucker KL, Graubard BI, McComb RD, Potischman NA, et al. Diet and risk of adult glioma in Eastern Nebraska, United States. Cancer Causes Control. 2002. 13:647–655.
9. Smith-Warner SA, Ritz J, Hunter DJ, Albanes D, Beeson WL, van den Brandt PA, et al. Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiol Biomarkers Prev. 2002. 11:987–992.
10. Klassen AC, Platz EA. What can geography tell us about prostate cancer? Am J Prev Med. 2006. 30:Suppl 2. S7–S15.
11. Kuller LH. Dietary fat and chronic disease: epidemiologic overview. J Am Diet Assoc. 1997. 97:Suppl 7. S9–S15.
12. Swyer G. The cholesterol content of normal and enlarged prostates. Cancer Res. 1942. 2:372–375.
13. Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest. 2005. 115:959–968.
14. Keller RK, Arnold TP, Fliesler SJ. Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. J Lipid Res. 2004. 45:347–355.
15. Fiorenza AM, Branchi A, Sommariva D. Serum lipoprotein profile in patients with cancer. A comparison with non-cancer subjects. Int J Clin Lab Res. 2000. 30:141–145.
16. Bravi F, Scotti L, Bosetti C, Talamini R, Negri E, Montella M, et al. Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer. Ann Oncol. 2006. 17:1014–1017.
17. Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willet WC, Giovannucci E. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control. 2001. 12:557–567.
18. Villers AA, McNeal JE, Redwine EA, Freiha FS, Stamey TA. The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol. 1989. 142:763–768.
19. de la Taille A, Rubin MA, Bagiella E, Olsson CA, Buttyan R, Burchardt T, et al. Can perineural invasion on prostate needle biopsy predict prostate specific antigen recurrence after radical prostatectomy? J Urol. 1999. 162:103–106.
20. Ozcan F. Correlation of perineural invasion on radical prostatectomy specimens with other pathologic prognostic factors and PSA failure. Eur Urol. 2001. 40:308–312.
21. Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS, et al. Statins and the risk of colorectal cancer. N Engl J Med. 2005. 352:2184–2192.
22. Graaf MR, Beiderbeck AB, Egberts AC, Richel DJ, Guchelaar HJ. The risk of cancer in users of statins. J Clin Oncol. 2004. 22:2388–2394.
23. Blais L, Desgagne A, LeLorier J. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study. Arch Intern Med. 2000. 160:2363–2368.
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