Journal List > Korean J Urol > v.49(1) > 1005048

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Maeng, Kang, and Huh: The Expression and Clinical Significance of the Minichromosome Maintenance (MCM) 7 Proliferation Markers in Urothelial Carcinomas of the Bladder
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(1): 12-17.

Published online: 31 January 2008

DOI: https://doi.org/10.4111/kju.2008.49.1.12

The Expression and Clinical Significance of the Minichromosome Maintenance (MCM) 7 Proliferation Markers in Urothelial Carcinomas of the Bladder

Young-Hee Maeng, Hyun Wook Kang2, Jung-Sik Huh1

Department of Patholgy, School of Medicine, Cheju University, Jeju, Korea.

1Department of Urology, School of Medicine, Cheju University, Jeju, Korea.

2Department of Forensic Medicine, School of Medicine, Cheju University, Jeju, Korea.

urohjs@cheju.ac.kr

Received 18 June 2007       Accepted 12 October 2007

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

The antibodies for minichromosome maintenance (MCM) proteins have been reported as potential proliferative markers and prognostic indicators in various human malignancies. The present study examined the expression pattern of MCM proteins in bladder carcinomas, and we also evaluated their prognostic significance as well as their potential applicability as proliferation markers.

Materials and Methods

Immunohistochemistry for MCM7 and Ki-67 was performed on paraffin sections from 47 cases of bladder carcinoma. The MCM7 and Ki-67 expressions were quantified and then analysis was carried out for determining the association between the expressions of MCM7 and Ki-67 and the clinicopathological parameters.

Results

A significant correlation existed between the expression rate of MCM7 and the histological grade (p<0.0001). The Ki-67 expression rate was significantly related to the tumor grade (p=0.002) and the pathological stage (p=0.011). On multivariate analysis, MCM7 was not found to be an independent prognostic factor for predicting the recurrence of bladder carcinoma.

Conclusions

The results suggest that MCM is a reliable proliferation marker, but not an independent predictive factor for recurrence of bladder carcinoma.

Keywords: Transitional cell carcinoma, MCM7 protein, Ki-67

Figures and Tables

Fig. 1
Immunoreactivity for minichromosome maintenance (MCM7) in low-grade papillary urothelial carcinoma (Expression group a, ×200).
kju-49-12-g001
Fig. 2
Immunoreactivity for minichromosome maintenance (MCM7) in high-grade papillary urothelial carcinoma (Expression group e, ×200).
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Table 1
Relationship of the minichromosome maintenance (MCM7) expression with the histological grade and stage
kju-49-12-i001

*a: 0-20%, b: 21-40%, c: 41-60%, d: 61-80%, e: 81-100%. †LMP: papillary urothelial neoplasm of low malignant potential, Low: papillary urothelial carcinoma, low-grade, High: papillary urothelial carcinoma, high-grade. ‡p-value by chi-square test for trend

Table 2
Relationship of the Ki-67 expression with the histological grade and stage
kju-49-12-i002

*a: 0-20%, b: 21-40%, c: 41-60%, d: 61-80%, e: 81-100%. †LMP: papillary urothelial neoplasm of low malignant potential, Low: papillary urothelial carcinoma, low-grade, High: papillary urothelial carcinoma, high-grade. ‡p-value by chi-square test for trend

Table 3
Multivariate COX regression analysis on the contribution of various factors for the prediction of recurrence
kju-49-12-i003

RR: relative risk, CI: confidence interval. *LMP: papillary urothelial neoplasm of low malignant potential, Low grade: papillary urothelial carcinoma, low-grade, High grade: papillary urothelial carcinoma, high-grade

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