Journal List > Korean J Urol > v.49(11) > 1005017

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Choi, Lee, Han, and Chang: Long Term Effectiveness of Doxazosin in Men with Lower Urinary Tract Symptoms Suggesting of Benign Prostatic Hyperplasia
Original Article
Korean Journal of Urology

Korean Journal of Urology 2008; 49(11): 1003-1006.

Published online: 30 November 2008

DOI: https://doi.org/10.4111/kju.2008.49.11.1003

Long Term Effectiveness of Doxazosin in Men with Lower Urinary Tract Symptoms Suggesting of Benign Prostatic Hyperplasia

Jun Choi, Jeong Oh Lee, Bo Hyun Han, Hyuk Soo Chang1

Department of Urology, Maryknoll Hospital, Busan, Korea.

1Department of Urology, Keimyung University School of Medicine, Daegu, Korea.

sangraal@dsmc.or.kr

Received 9 June 2008       Accepted 1 September 2008

Copyright © 2008 The Korean Urological Association

Abstract

Purpose

The aim of this study was to evaluate the efficacy of doxazosin over 6 years in men with benign prostatic hyperplasia (BPH).

Materials and Methods

This retrospective study enrolled 33 patients with symptomatic BPH who were prescribed an alpha-blocker from January 1999 to December 2000. We evaluated the changes of International Prostate Symptom Score (IPSS), maximal flow rate (Qmax), quality of life (QoL) and residual urine volume (RUV) between before and after 6-year of treatment.

Results

The percentages of improvement were 40.2% in total IPSS, 40.6% in obstructive symptom, 39.4% in irritative symptom, 44.7% in QoL, 124.8% in Qmax, 33.5% in RUV (p<0.05). Three patients (9.1%) experienced acute urinary retention and BPH-related surgery was performed in 6 patients (18.2%).

Conclusions

Our study revealed that long-term treatment over 6 years with alpha-blocker resulted in significant improvements in the IPSS, QoL, Qmax and RUV.

Keywords: Benign prostatic hyperplasia, Doxazosin

Figures and Tables

Table 1
Changes of total, obstructive and irritative symptom scores, maximal flow rate, and residual urine volume after doxazosin therapy
kju-49-1003-i001

IPSS: International Prostate Symptom Score

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