Chong Won Bak; Sang Jin Yoon; Han Chung

doi:10.4111/kju.2007.48.5.517

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Bak, Yoon, and Chung: Effects of an α-blocker and Terpene Mixture for Pain Control and Spontaneous Expulsion of Ureter Stone

Original Article

Korean Journal of Urology

Korean Journal of Urology 2007; 48(5): 517-521.

Published online: 31 May 2007

DOI: https://doi.org/10.4111/kju.2007.48.5.517

Effects of an α-blocker and Terpene Mixture for Pain Control and Spontaneous Expulsion of Ureter Stone

Chong Won Bak, Sang Jin Yoon, Han Chung

Department of Urology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.

Corresponding author (urohana@gilhospital.com)

Received 8 December 2006 Accepted 18 April 2007

Abstract

Purpose

It was known that α-1 receptors are present in ureteral smooth muscle. We aimed to reveal the effect of an α-blocker (tamsulosin) and terpene mixture (Rowatinex®) on the expulsion of ureter stone (size less than 1cm), as well as its affect on the relief of pain.

Materials and Methods

The patients were classified into group A in which the size of the ureter stone less than 4mm (144 subjects) and group B in which the size of stone was between 4mm and 10mm (48 patients). Each study group was also further divided into 3 sub-groups: group 1 with analgesics only, group 2 with Rowatinex® as well as analgesics, and group 3 with 0.4mg of tamsulosin as well as analgesics.

Results

It was shown that the expulsion rates of ureter stone in sub-group 1 of group A, at the end of first week, was statistically lower (p<0.05) compared to that of sub-group 2 with Rowatinex®. It was also shown that compared to sub-group 1, the expulsion rate of ureter stone at the end of first week in sub-group 3 was statistically significant (p<0.05). Compared to the consumed amount of analgesics in group A, it was revealed that sub-group 2 and sub-group 3 used statistically fewer ampules of than sub-group 1 (p<0.05).

Conclusions

Our study clearly showed that both α-blocker and Rowatinex® are effective means of controlling colicky pain and they speed up excretion of ureter stones that are less than 4mm in size, at the end of first week. Therefore, we conclude that an alpha-blocker and Rowatinex® should be considered as an adjuvant regimen and this is beneficial for patients with ureter stone less than 4mm in size.

Keywords: Ureteral calculi, α-blocker, Terpenes

Figures and Tables

Table 1

Characteristics of groups A and B

^*Group 1: ketorolac tromethamine (Tarasyn®), ^†Group 2: ketorolac tromethamine (Tarasyn®)+Rowatinex®, ^‡Group 3: ketorolac tromethamine (Tarasyn®)+tamsulosin (Harnal®), ^§Group A: stone size (less than 0.4cm), ^∥Group B: stone size (0.4-1cm)

Table 2

Stone location

Group 1 vs. Group 2 (p>0.05), Group 1 vs. Group 3 (p>0.05), Group 2 vs. Group 3 (p>0.05), chi-square test

Table 3

Expulsion rate of ureter stone

Group A: ^*Group 1 vs. Group 2 (p<0.05), Group 1 vs. Group 3 (p<0.05), Group 2 vs. Group 3 (p>0.05), ^†Group 1 vs. Group 2 (p>0.05), Group 1 vs. Group 3 (p<0.05), Group 2 vs. Group 3 (p<0.05), Group B: ^‡Group 1 vs. Group 2 (p>0.05), Group 1 vs. Group 3 (p>0.05), Group 2 vs. Group 3 (p>0.05), chi-square test

Table 4

Injective analgesic use of each group

^*Group A: Group 1 vs. Group 2 (p>0.05), Group 1 vs. Group 3 (p>0.05), Group 2 vs. Group 3 (p>0.05), ^†Group A: Group 1 vs. Group 2 (p<0.05), Group 1 vs. Group 3 (p<0.05), Group 2 vs. Group 3 (p>0.05), chi-square test

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