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Chung: Medical Management for Benign Prostatic Hyperplasia
Review Article
Korean Journal of Urology

Korean Journal of Urology 2007; 48(3): 233-243.

Published online: 31 March 2007

DOI: https://doi.org/10.4111/kju.2007.48.3.233

Medical Management for Benign Prostatic Hyperplasia

Byung Ha Chung

Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author (chung646@yumc.yonsei.ac.kr)

Copyright © 2007 The Korean Urological Association

Abstract

The aim of therapy for benign prostatic hyperplasia (BPH) is to improve quality of life by providing symptom relief and an increased maximum flow rate, as well as reduce disease progression and the development of new morbidities. There has been an enormous decline in the popularity of surgery and it is now apparent that medication is the most frequently used treatment for BPH. This has arguably therefore been the most major change in urological clinical practice in the last decade. Currently α1-adrenoceptor antagonists are the commonest medical therapy, and are thought to act by relaxing prostatic smooth muscle, the neural or so-called 'dynamic' component of BPO. 5α-reductase inhibitors are another option for BPH, which reduce prostatic mass and therefore the mechanical or 'static' component of benign prostatic obstruction (BPO). Another group of agents are the phytotherapeutic extracts, which act via various mechanisms, many as yet poorly defined. This review critically assesses existing publications relating to the medical management of BPH.

Keywords: Benign Prostatic Hyperplasia, Medical Management

Figures and Tables

Table 1
Drugs for treatment of benign prostatic hyperplasia
kju-48-233-i001

GnRH: gonadotropin releasing hormone

Table 2
Effect of alpha-blocker on benign prostatic hyperplasia in Korea
kju-48-233-i002

GITS: gastrointestinal therapeutic system, IPSS: International Prostate Symtom Score, Qmax: maximum urinary flow rate. *no data.

Table 3
VA cooperative study
kju-48-233-i003

VA: veterans affair, chi-squre (p=0.002)

Table 4
IPSS changing after medical management for benign prostatic hyperplasia
kju-48-233-i004

IPSS: International Prostate Symptom Score, VA-COOP: veterans affair cooperative, PREDICT: prospective European doxazosin and combined therapy, MTOPS: medical therapy of prostatic symptom.

*:p<0.05, †:p<0.001

Table 5
Changes of urologic variables in MTOPS study
kju-48-233-i005

IPSS: International Prostate Symptom Score, MTOPS: medical therapy of prostatic symptom

Table 6
Effect of combination therapy in Korea
kju-48-233-i006

IPSS: International Prostate Symptom Score, Qmax: maximum urinary flow rate. *no data.

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