Journal List > Korean J Urol > v.48(2) > 1004866

Kim, Sung, Kim, Yoon, Kim, and Yoo: Leydig Cell Tumor in Cryptorchid Testis

Abstract

Leydig cell tumors are rare, constituting only 1-3% of all testicular tumors; but they are still the focus of interest due to the difficulties in determining their exact nature and subsequent type of treatment. Generally, there appears to be no association with cryptorchidism, but there have been reports of Leydig cell tumors in cryptorchid testes. Herein, a case of a Leydig cell tumor in cryptorchidism is reported.

Figures and Tables

Fig. 1
An abdominal-pelvic computed tomography (CT) scan shows an approximately 9.2×7.3cm sized homogeneous mass lesion in the left inguinal canal. Multiple tiny calcifications and a small low density area can be observed, suspicious of necrosis.
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Fig. 2
The cross section of the gross finding shows a yellowish round, solid mass.
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Fig. 3
Histological features of the Leydig cell tumor of the testis. (A) Large polygonal cells, with abundant eosinophilic cytoplasm and crystaloid of Reinke in the interstitium (B) pronounced nuclear and cellular pleomorphism (H&E, ×400).
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Fig. 4
Immunohistochemistry showing positive staining for α-inhibin (A: Inhibin, ×200) and negative staining for cytokeratin (B: CK, ×200).
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References

1. Ritchey M. Walsh PC, Retik AB, Stamey TA, Vaughan ED, Wein AJ, editors. Pediatric urology oncology. Campbell's urology. 2001. 8th ed. Philadelphia: Saunders;2498.
2. Lee JJ, Park CG, Kim SJ, Shin KY, Park YW, Park HY, et al. A case of malignant Leydig cell tumor. Korean J Urol. 1997. 38:97–101.
3. Loyd E, Boorjian S. A painless testicular mass in a 50-year-old man Leydig cell tumor of the testis, microcystic variant. Arch Pathol Lab Med. 2006. 130:e39–e40.
4. Bertram KA, Bratloff B, Hodges GF, Davidson H. Treatment of malignant Leydig cell tumor. Cancer. 1991. 68:2324–2329.
5. Kim JH, Yang HJ, Yoon JH, Choi MS, Lee DH, Moom KH, et al. Non-palpable and asymptomatic Leydig cell tumor. Korean J Urol. 2006. 47:211–213.
6. Na SS, Choi NG. A case of Leydig cell tumor of testis in child. Korean J Urol. 1988. 29:867–870.
7. Komai Y, Urushibara M, Morimoto S, Sakai K, Kobanawa K. Male infertility in an adult with unilateral Leydig cell tumor of the undescended testis. Hinyokika Kiyo. 2004. 50:881–883.
8. John NE, Guido S, Jonathan IE, Isabell AS. Tumors of the urinary system and male genital organs. 2004. 1st ed. Albany: WHO publication center;250–251.
9. Drut R, Wludarski S, Segatelli V, de Oliveira E, Barbosa A, Matheus A, et al. Leydig cell tumor of the testis with histological and immunohistochemical features of malignancy in a 1-year-old boy with isosexual pseudoprecocity. Int J Surg Pathol. 2006. 14:344–348.
10. Shannon BA, Vasudevan A, Cohen RJ. Abnormal Leydig cells in cryptorchid testes: a report of two cases. Pathology. 2003. 35:269–271.
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