The Changes of Serum Prostate-specific Antigen after Ejaculation

Ju Hyun Lim; Sang Deuk Kim; Kyung Soo Choi; Seong Beom Choi; Dae Woong Kim; Jong Kwan Park

doi:10.4111/kju.2007.48.12.1247

Journal List > Korean J Urol > v.48(12) > 1004839

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Lim, Kim, Choi, Choi, Kim, and Park: The Changes of Serum Prostate-specific Antigen after Ejaculation

Original Article

Korean Journal of Urology

Korean Journal of Urology 2007; 48(12): 1247-1250.

Published online: 31 December 2007

DOI: https://doi.org/10.4111/kju.2007.48.12.1247

The Changes of Serum Prostate-specific Antigen after Ejaculation

Ju Hyun Lim¹, Sang Deuk Kim¹, Kyung Soo Choi¹, Seong Beom Choi¹, Dae Woong Kim¹, Jong Kwan Park^1,²

¹Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.

²Institute for Medical Sciences and Research Institute of Clinical Medicine of Chonbuk National University, Clinical Trial Center of Chonbuk National University Hospital, Jeonju, Korea.

Corresponding author (rain@chonbuk.ac.kr)

Received 30 July 2007 Accepted 15 October 2007

Abstract

Purpose

Prostatic manipulation and surgery have been shown to increase serum prostate-specific antigen (PSA). We studied the effect of ejaculation on the serum PSA levels.

Materials and Methods

We evaluated 131 men (16 to 64 years old) who had no history of surgery or inflammatory disease of the urogenital tract. The total serum PSA, free PSA, serum total testosterone, free testosterone, luteinizing hormone (LH), and follicular stimulating hormone (FSH) were evaluated 1 hour after ejaculation.

Results

A PSA level was detected in all the men. There were statistically significant changes of the serum PSA level before and after ejaculation. We compared the parameters between increased PSA group and the decreased PSA group. There were significant differences between the two groups on comparison of the total prostate volume (25.4±3.6g vs 15.1±4.2g, respectively) and the transition zone volume (7.1±2.7g vs 5.3±1.1g, respectively).

Conclusions

Based on our data, ejaculation affects the serum PSA concentration in young men, and there seems to be a physiological relationship between ejaculation and the PSA level. The larger the prostate volume, the more ejaculation has an effect on the serum PSA level.

Keywords: Prostate-specific antigen, Prostate, Ejaculation

Figures and Tables

Table 1

Patients characteristics

SD: standard deviation

Table 2

Serum concentration of PSA and testosterone before and after ejaculation

PSA: prostate-specific antigen

Table 3

Comparison of parameters between the two groups

I: increased total PSA group after ejaculation, II: decreased total PSA group after ejaculation, PSA: prostate-specific antigen

References

1. Lilja H. A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J Clin Invest. 1985. 76:1899–1903.

2. Roehrborn CG, Boyle P, Gould AL, Waldstreicher J. Serum prostate-specific antigen as a predictor of prostate volume in men with benign prostatic hyperplasia. Urology. 1999. 53:581–589.

3. Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E. Prostate- specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med. 1987. 317:909–916.

4. Simak R, Madersbacher S, Zhang ZF, Maier U. The impact of ejaculation on serum prostate specific antigen. J Urol. 1993. 150:895–897.

5. McAleer JK, Gerson LW, McMahon D, Geller L. Effect of digital rectal examination (and ejaculation) on serum prostate-specific antigen after twenty-four hours. A randomized, prostpective study. Urology. 1993. 41:111–112.

6. Glenski WJ, Klee GG, Bergstralh EJ, Oesterling JE. Prostate-specific antigen: establishment of the reference range for the clinically normal prostate gland and the effect of digital rectal examination, ejaculation and time on serum concentrations. Prostate. 1992. 21:99–110.

7. Lilja H, Oldbring J, Rannevik G, Laurell CB. Seminal vesical-secreted proteins and their reactions during gelation and liquefaction of human semen. J Clin Invest. 1987. 80:281–285.

8. Sensabaugh GF. Isolation and characterization of a semen-specific protein from human seminal plasma: a potential new marker for semen identification. J Forensic Sci. 1978. 23:106–115.

9. Oesterling JE, Rice DC, Glenski WJ, Bergstralh EJ. Effect of cystoscopy, prostate biopsy, and transurethral resection of prostate on serum prostate-specific antigen concentration. Urology. 1993. 42:276–282.

10. Tchetgen MB, Song JT, Strawderman M, Jacobsen SJ, Oesterling JE. Ejaculation increases the serum prostate-specific antigen concentration. Urology. 1996. 47:511–516.

11. Herschman JD, Smith DS, Catalona WJ. Effect of ejaculation on serum total and free prostate-specific antigen concentrations. Urology. 1997. 50:239–243.

12. Cecchi M, Sepich CA, Felipetto R, Vigano L, Pagni G, Minervini R, et al. Serum prostate specific antigen variations after ejaculation : a preliminary study. European Association of Urology, 11th Congress Abstract Book. 1994. 148.

13. Moyard R, Song JT, Belville WD. The impact of ejaculation on serum prostate specific antigen (PSA) levels in men over the age of 40. J Urol. 1994. 151:(Suppl). 400. abstract 689.

14. Heidenreich A, Vorreuther R, Neubauer S, Westphal J, Engelmann UH, Moul JW. The influence of ejaculation on serum levels of prostate specific antigen. J Urol. 1997. 157:209–211.

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