PDF
ePub
Citation
Print
Abstract
Purpose
The natural history and prognosis of transitional cell carcinoma (TCC) of the bladder in young patients remain a matter of debate. This study aimed to evaluate whether TCC of the bladder in young patients is biologically different from that found in elderly patients.
Materials and Methods
The medical records of 21 patients presenting with TCC of the bladder at 40 years of age and younger (group 1) were reviewed and compared with those of 94 patients who were diagnosed with bladder TCC at 51 years of age and older (group 2).
Results
The initial stage distribution was similar with 85.7% and 79.8% of patients presenting with superficial TCC in group 1 and 2, respectively. The gross hematuria as a presenting symptom, multiplicity of tumor mass, T stage, N stage, M stage, concomitant carcinoma in situ (CIS) and grade were not significantly different between the two groups. There was no difference in the cancer-specific survival rate between the two groups. For the cases with superficial TCC, no difference was observed in the disease-free survival rate or progression-free survival rate between the two groups.
Conclusions
TCC of the bladder in patients 40 years old or less has a similar clinicopathological distribution and disease outcome to those observed in elderly patients. It is suggested that the management and follow-up of TCC of the bladder in young patients should be the same as those for elderly patients.
Figures and Tables
Fig. 1
Kaplan-Meier cancer-specific survival curves showed that there was no difference in the survival rate between the two groups (p=0.905).
Fig. 2
Kaplan-Meier disease-free survival curves in patients with superficial bladder cancer. No difference was observed in the survival rate between the two groups (p=0.821).
Fig. 3
Kaplan-Meier progression-free survival curves in patients with superficial bladder cancer. No difference was observed in the survival rate between the two groups (p=0.595).
References
1. Donat SM. Evaluation and follow-up strategies for superficial bladder cancer. Urol Clin North Am. 2003. 30:765–776.
2. Kim WJ, Chung JI, Hong JH, Kim CS, Jung SI, Yoon DK. Epidemiological study for urologic cancer in Korea (1998-2002). Korean J Urol. 2004. 45:1081–1088.
3. Fleshner N, Kondylis F. Droller MJ, editor. Demographics and epidemiology of urothelial cancer of the urinary bladder. Urothelial tumors. 2004. Hamilton: BC Decker;1–16.
4. Iori F, De Dominicis C, Liberti M, Frioni D, Vahedi M, Leonardo C, et al. Superficial bladder tumors in patients under 40 years of age: clinical, prognostic and cytogenetic aspects. Urol Int. 2001. 67:224–227.
5. Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI. Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the world health organization 2004 bladder consensus classification. J Urol. 2005. 174:1976–1980.
6. Benson RC Jr, Tomera KM, Kelalis PP. Transitional cell carcinoma of the bladder in children and adolescents. J Urol. 1983. 130:54–55.
7. Madgar I, Goldwasser B, Nativ O, Hanani Y, Jonas P. Long-term followup of patients less than 30 years old with transitional cell carcinoma of bladder. J Urol. 1988. 139:933–934.
8. McCarthy JP, Gavrell GJ, LeBlanc GA. Transitional cell carcinoma of bladder in patients under thirty years of age. Urology. 1979. 13:487–489.
9. Kim WJ, Lee SE, Kim YK. Transitional cell carcinoma of the bladder in the first three decades of life. Korean J Urol. 1986. 27:255–258.
10. Chang SY, Ma CP. Transitional cell carcinoma of the urinary bladder in patients under 40 years of age. Br J Urol. 1987. 60:343–344.
11. Stokes MA, Kelly DG. Transitional cell carcinoma in patients under forty years of age. Br J Urol. 1987. 59:536–539.
12. Erozenci A, Ataus S, Pekyalcin A, Kural A, Talat Z, Solok V. Transitional cell carcinoma of the bladder in patients under 40 years of age. Int Urol Nephrol. 1994. 26:179–182.
13. Witjes JA, Debruyne FM. Bladder carcinoma in patients less than 40 years of age. Urol Int. 1989. 44:81–83.
14. Wan J, Grossman HB. Bladder carcinoma in patients age 40 years or younger. Cancer. 1989. 64:178–181.
15. Fitzpatrick JM, Reda M. Bladder carcinoma in patients 40 years old or less. J Urol. 1986. 135:53–54.
16. Yossepowitch O, Dalbagni G. Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. J Urol. 2002. 168:61–66.
17. Cherrie RJ, Lindner A, deKernion JB. Transitional cell carcinoma of bladder in first four decades of life. Urology. 1982. 20:582–584.
18. Kutarski PW, Padwell A. Transitional cell carcinoma of the bladder in young adults. Br J Urol. 1993. 72:749–755.
19. Johnson DE, Hillis S. Carcinoma of the bladder in patients less than 40 years old. J Urol. 1978. 120:172–173.
20. Kurz KR, Pitts WR, Vaughan ED Jr. The natural history of patients less than 40 years old with bladder tumors. J Urol. 1987. 137:395–397.
21. Migaldi M, Rossi G, Maiorana A, Sartori G, Ferrari P, De Gaetani C, et al. Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study. BJU Int. 2004. 94:311–316.
22. Seon YB, Kim JH, Kwon SS, Kim YH, Park HJ, Kwon CH, et al. Two cases of transitional cell carcinoma of the bladder in patients younger than 20 years old. Korean J Urol. 1998. 39:283–285.
23. American Joint Committee on Cancer. AJCC cancer staging manual. 1997. 5th ed. Philadelphia: Lippincott-Raven;241–243.
24. Epstein JI, Amin MB, Reuter VR, Mostofi FK. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol. 1998. 22:1435–1448.
XML Download