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Kim, Kim, and Lee: Prognosis Associated with Thrombocytosis in Renal Cell Carcinoma
Original Article
Korean Journal of Urology

Korean Journal of Urology 2007; 48(11): 1099-1103.

Published online: 30 November 2007

DOI: https://doi.org/10.4111/kju.2007.48.11.1099

Prognosis Associated with Thrombocytosis in Renal Cell Carcinoma

Kong Jo Kim, Doo Sang Kim, Nam Kyu Lee

Department of Urology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea.

Corresponding author (urokds@schch.co.kr)

Received 4 June 2007       Accepted 4 September 2007

Copyright © 2007 The Korean Urological Association

Abstract

Purpose

Thrombocytosis has been reported in many types of malignancies and it has been studied as a prognostic factor. To better define the relationship between the platelet count and survival, we performed a retrospective analysis of patients with thrombocytosis and renal cell carcinoma, and some of whom had a lower survival rate than those with a normal platelet count.

Materials and Methods

We reviewed the medical records of patients with renal cell carcinoma and who had undergone radical nephrectomy between January, 1995 and December, 2004. A total of 112 patients were treated by radical nephrectomy for renal cell carcinoma. Among them, 67 patients without primary thrombocytosis, no familial history of renal cell carcinoma and no history of adjuvant therapy were enrolled in this study. The patients were divided into a normal platelet count group and a thrombocytosis group (greater than 400,000/µl) according to the perioperative platelet count. The two groups were compared pathologically and clinically, including comparing the prognosis.

Results

The mean follow-up was 55.8 months (range: 21 to 80). Thrombocytosis was present in 19 patients. The mean survival for the normal platelet count group was 67.8±39.36 months, compared with 41.4±30.65 months for the thrombocytosis group (p<0.05). The difference of survival between the 2 groups remained significant when controlling for the established prognostic indicators like the pathological stage, nuclear grade and cell types.

Conclusions

This study documents the association of thrombocytosis with decreased survival in patients with renal cell carcinoma. The peri-operative platelet count appears to be a significant independent predictor for determining the prognosis for patients with renal cell carcinoma.

Keywords: Thrombocytosis, Carcinoma, renal cell, Prognosis

Figures and Tables

Fig. 1
Kaplan-Meier survival curves according to the platelet counts. (1) Platelet count less than 400,000/µl and (2) platelet count of 400,000/µl or greater (p<0.01).
kju-48-1099-g001
Table 1
Patient characteristics of the 67 cases of renal cell carcinoma
kju-48-1099-i001
Table 2
Variables between the patients with normal platelet count and the patients with thrombocytosis
kju-48-1099-i002

SD: standard deviation

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