A 21 year-old man visited our clinic complaining of a penile skin defect and discharge after self-injection of Squalene into his penis to facilitate an erection and increase his potency. The compromised skin and subcutaneous tissue were completely removed, and a split-thickness skin graft performed using the skin from the right side of the groins. This method was a simple, one stage operation, with a shortened hospital stay. Although a few studies on the oral administration of Squalene have been performed, a Squalene injection for penile augmentation has seldom been reported. Herein, a case in which a patient injected Squalene oil into his penis is reported and the subsequent treatment result described.