Cystic adventitial disease of the popliteal artery is rare condition, but it is an important cause of peripheral vascular insufficiency in young men. Conventional angiography or MR imaging has traditionally been considered as the study of choice to diagnose this disease. We experienced a case of cystic adventitial disease of the popliteal artery that was diagnosed by 16-slice MDCT angiography, and this imaging modality displayed an accurate diagnostic capability for this disease.