Granulocytic sarcoma is an uncommon clinical condition that usually occurs in the bone, periosteum, soft tissue, lymph node and skin, and this is rarely seen in the gastrointestinal tract. To the best of our knowledge, few cases of granulocytic sarcoma in the small bowel have been reported in the English literature. We present here a case of nonleukemic granulocytic sarcoma of the ileum in a 42-year-old patient who had no evidence of blood or bone marrow involvement that would have been suggestive of acute leukemia or myeloproliferative disorders.