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Abstract
Periorbital edema is a rare manifestation of systemic lupus erythematosus (SLE). We describe here a patient with bilateral periorbital edema as a presenting symptom of SLE. A 23-year-old woman was admitted for a sudden onset of severe periorbital edema that developed 7 days previously. On the basis of the malar rash, arthritis of the right hand and left wrist, leukopenia, proteinuria and the positive anti-nuclear and anti-dsDNA antibodies, she was diagnosed with SLE. Kidney biopsy revealed lupus nephritis (WHO class IV). After treatment with high dose of steroids, intravenous cyclophosphamide and daily hydroxychloroquine, her symptoms resolved, including the periorbital edema. She was discharged with prescriptions for prednisolone and hydroxychloroquine and she remains well.
REFERENCES
1). Wallace DJ., Hahn BH. Dubois' Lupus Erythematosus. 7th ed.p. 16. Philadelphia, Lippincott Williams & Wilkins;2007.
2). Tuffanelli DL., Dubois EL. Cutaneous Manifestations of Systemic Lupus Erythematosus. Arch Dermatol. 1964. 90:377–86.
3). Gomez-Puerta JA., Levy S., Khamashta MA., Hughes GR. Periorbital oedema in systemic lupus erythematosus. Lupus. 2003. 12:866–9.
4). Marks J., Birkett DA., Shuster S. “Capillary permeability” in patients with collagen vascular diseases. Br Med J. 1972. 1:782–4.
5). Thong BY., Thumboo J., Howe HS., Feng PH. Life-threatening angioedema in systemic lupus erythematosus. Lupus. 2001. 10:304–8.
6). Williams WL., Ramos-Caro FA. Acute periorbital mucinosis in discoid lupus erythematosus. J Am Acad Dermatol. 1999. 41:871–3.
7). Fossaluzza V., Dal Mas P. Proptosis and systemic lupus erythematosus. Clin Exp Rheumatol. 1987. 5:192–3.
8). Grimson BS., Simons KB. Orbital inflammation, myositis, and systemic lupus erythematosus. Arch Ophthalmol. 1983. 101:736–8.
9). Donzis PB., Insler MS., Buntin DM., Gately LE. Discoid lupus erythematosus involving the eyelids. Am J Ophthalmol. 1984. 98:32–6.
10). Huey C., Jakobiec FA., Iwamoto T., Kennedy R., Farmer ER., Green WR. Discoid lupus erythematosus of the eyelids. Ophthalmology. 1983. 90:1389–98.
11). Inuzuka M., Tomita K., Tokura Y., Takigawa M. Lupus erythematosus profundus with unusual skin manifestation: subcutaneous nodules coexisting with eyelid plaques. J Dermatol. 2001. 28:437–41.
12). Norden D., Weinberg J., Schumacher HR., Keenan G., Freundlich B. Bilateral periorbital edema in systemic lupus erythematosus. J Rheumatol. 1993. 20:2158–60.
13). Sehgal VN., Rege VL., Vadiraj SN. An unusual cutaneous manifestation of systemic lupus erythematosus. Arch Dermatol. 1971. 103:463–4.
14). Cacoub P., Fremeaux-Bacchi V., De Lacroix I., Guillien F., Kahn MF., Kazatchkine MD, et al. A new type of acquired C1 inhibitor deficiency associated with systemic lupus erythematosus. Arthritis Rheum. 2001. 44:1836–40.
15). Kwon OY., Seo CH., Jung ST., Nahm DH., Park HS. Angioedema-like facial swelling as a first manifestation of systemic lupus erythematosus. J Asthma Allergy Clin Immunol. 1998. 18:90–5.
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