Journal List > J Korean Rheum Assoc > v.17(1) > 1003772

Lee, Youn, Kang, and Lee: A Case of Dermatomyositis That Developed after Repeated Filler Material Injections for Cosmetic Purposes

Abstract

Dermatomyositis and polymyositis are uncommon, acquired idiopathic inflammatory myopathies of an unknown etiology. Although there are 9 reported cases in the literature of developing dermatomyositis or polymyositis after collagen dermal injection, it is still controversial whether there is a link between injectable filler materials and autoimmune diseases, and specifically dermatomyositis/polymyositis. We experienced a case of a 40-year-old woman who developed dermatomyositis after repeated injections of multiple filler materials, including collagen for cosmetic purposes, which suggests a temporal relation between the two factors. The benefit-to-risk ratio should be assessed for repeated cosmetic surgical procedures that use filler materials.

REFERENCES

1). Sanchez-Guerrero J., Schur PH., Sergent JS., Liang MH. Silicone breast implants and rheumatic disease. Clinical, immunologic, and epidemiologic studies. Arthritis Rheum. 1994. 37:158–68.
2). Kessler DA. The basis of the FDA's decision on breast implants. N Engl J Med. 1992. 326:1713–5.
crossref
3). Clark DP., Hanke CW., Swanson NA. Dermal implants: safety of products injected for soft tissue augmentation. J Am Acad Dermatol. 1989. 21:992–8.
crossref
4). Cukier J., Beauchamp RA., Spindler JS., Spindler S., Lorenzo C., Trentham DE. Association between bovine collagen dermal implants and a dermatomyositis or a polymyositis-like syndrome. Ann Intern Med. 1993. 118:920–8.
crossref
5). Koeger AC., Lang T., Alcaix D., Milleron B., Rozenberg S., Chaibi P, et al. Silica-associated connective tissue disease. A study of 24 cases. Medicine (Baltimore). 1995. 74:221–37.
crossref
6). Oddis CV., Conte CG., Steen VD., Medsger TA Jr. Incidence of polymyositis-dermatomyositis: a 20-year study of hospital diagnosed cases in Allegheny County, PA 1963-1982. J Rheumatol. 1990. 17:1329–34.
7). Goldstein R., Duvic M., Targoff IN., Reichlin M., McMenemy AM., Reveille JD, et al. HLA-D region genes associated with autoantibody responses to histidyl-transfer RNA synthetase (Jo-1) and other translation-related factors in myositis. Arthritis Rheum. 1990. 33:1240–8.
crossref
8). Magid SK., Kagen LJ. Serologic evidence for acute toxoplasmosis in polymyositis-dermatomyositis. Increased frequency of specific anti-toxoplasma IgM antibodies. Am J Med. 1983. 75:313–20.
9). Christensen ML., Pachman LM., Schneiderman R., Patel DC., Friedman JM. Prevalence of Coxsackie B virus antibodies in patients with juvenile dermatomyositis. Arthritis Rheum. 1986. 29:1365–70.
crossref
10). Elson ML. Injectable collagen and autoimmune disease. J Dermatol Surg Oncol. 1993. 19:165–8.
crossref
11). Singh G., Fries JF. Autoimmune disease and collagen dermal implants. Ann Intern Med. 1994. 120:524–5.
crossref
12). Elson ML. The role of skin testing in the use of collagen injectable materials. J Dermatol Surg Oncol. 1989. 15:301–3.
crossref
13). McClelland M., Delustro F. Evaluation of antibody class in response to bovine collagen treatment in patients with urinary incontinence. J Urol. 1996. 155:2068–73.
crossref
14). Vanderveen EE., McCoy JP Jr., Schade W., Kapur JJ., Hamilton T., Ragsdale C, et al. The association of HLA and immune responses to bovine collagen implants. Arch Dermatol. 1986. 122:650–4.
crossref
15). McCoy JP Jr., Schade WJ., Siegle RJ., Waldinger TP., Vanderveen EE., Swanson NA. Characterization of the humoral immune response to bovine collagen implants. Arch Dermatol. 1985. 121:990–4.
crossref

Fig. 1.
Diffuse facial erythema with a heliotrope rash and the patient showed with edematous violet-colored eyelids.
jkra-17-46f1.tif
Fig. 2.
Slightly elevated violaceous papules and plaques of thickened, scaly skin over the hand knuckles (Gottron's papules).
jkra-17-46f2.tif
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