A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis

Seong Oh Park; Ji Hyun Lee

doi:10.4078/jkra.2010.17.4.422

Journal List > J Korean Rheum Assoc > v.17(4) > 1003764

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Park and Lee: A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis

Original Article

J Korean Rheum Assoc 2010;17(4):422-425.

Published online: 23 December 2010

DOI: https://doi.org/10.4078/jkra.2010.17.4.422

A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis

Seong Oh Park, Ji Hyun Lee

Department of Rheumatology, Maryknoll Hospital, Busan, Korea

Received 10 June 201011 August 2010 Accepted 12 August 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximab-induced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.

Keywords: Infliximab, Bullous pemphigoid, Rheumatoid arthritis

REFERENCES

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Fig. 1.

Multiple vesicles and erosion on groin.

Fig. 2.

Vesicle on third finger, left.

Fig. 3.

Subepidermal bullae was found with inflammatory infiltrates on the dermis (hematoxylin and eosin, ×100).

Fig. 4.

Immunofluorescent stain of patient's serum shows linear pattern of IgG deposition on the epidermal basement membrane of normal skin.

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